Evidence map›Paper›PMID 34875740›Full record

ArticleClinical and experimental reproductive medicine2021

Adipose tissue-derived mesenchymal stem cells reduce endometriosis cellular proliferation through their anti-inflammatory effects.

Fatma Y Meligy, Dalia A Elgamal, Lobna A Abdelzaher, Maha Y Khashbah, Mohamed A El-Mokhtar, Ayat A Sayed, Abeer M Refaiy, Essam R Othman

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental reproductive medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Fatma Y MeligyDepartment of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Dalia A ElgamalDepartment of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Lobna A AbdelzaherReproductive Science Research Center, Faculty of Medicine, Assiut University, Assiut, Egypt.
Maha Y KhashbahReproductive Science Research Center, Faculty of Medicine, Assiut University, Assiut, Egypt.
Mohamed A El-MokhtarReproductive Science Research Center, Faculty of Medicine, Assiut University, Assiut, Egypt.
Ayat A SayedReproductive Science Research Center, Faculty of Medicine, Assiut University, Assiut, Egypt.
Abeer M RefaiyReproductive Science Research Center, Faculty of Medicine, Assiut University, Assiut, Egypt.
Essam R OthmanReproductive Science Research Center, Faculty of Medicine, Assiut University, Assiut, Egypt.
Assiut University · EG

Funding

Assiut Medical School Grants Office, Faculty of Medicine, Assiut University
6 · The paper itself

Abstract

objectiveEndometriosis is a chronic debilitating inflammatory condition characterized by the presence of endometrial tissues outside the uterine cavity. Pelvic soreness and infertility are the usual association. Due to the poor effectiveness of the hormone therapy and the high incidence of recurrence following surgical excision, there is no single effective option for management of endometriosis. Mesenchymal stem cells (MSCs) are multipotent stromal cells studied for their broad immunoregulatory and anti-inflammatory properties; however, their efficiency in endometriosis cases is still a controversial issue. Our study aim was to evaluate whether adipose tissue-derived MSCs (AD-MSCs) could help with endometriosis through their studied anti-inflammatory role.

methodsFemale Wistar rats weighting 180 to 250 g were randomly divided into two groups: group 1, endometriosis group; established by transplanting autologous uterine tissue into rats' peritoneal cavities and group 2, stem cell treated group; treated with AD-MSCs on the 5th day after induction of endometriosis. The proliferative activity of the endometriosis lesions was evaluated through Ki67 staining. Quantitative estimation of interferon γ, tumor necrosis factor-α, interleukin (IL)-6, IL-1β, IL-10, and transforming growth factor β expression, as well as immunohistochemical detection of CD68 positive macrophages, were used to assess the inflammatory status.

resultsThe size and proliferative activity of endometriosis lesions were significantly reduced in the stem cell treated group. Stem cells efficiently mitigated endometriosis associated chronic inflammatory reactions estimated through reduction of CD68 positive macrophages and the expression of the proinflammatory cytokines.

conclusionStem cell therapy can be considered a novel remedy in endometriosis possibly through its anti-inflammatory and antiproliferative properties.

Indexed as

CD68CytokinesEndometriosisKi67Mesenchymal stem cellsRats

Identifiers

PMID34875740
PMCPMC8651762
OpenAlexW3215658182

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.