Evidence map›Paper›PMID 34877488›Full record

ArticleiScience2021

A nonhuman primate model of vertical sleeve gastrectomy facilitates mechanistic and translational research in human obesity.

Julia L Nugent, Amar Singh, Keith M Wirth, Scott Hunter Oppler, Laura Hocum Stone, Jody L Janecek, Adam C Sheka, Scott Kizy, Meghan E G Moore, Christopher Staley and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Julia L NugentDepartment of Surgery, University of Minnesota, MN, USA.
Amar SinghDepartment of Surgery, University of Minnesota, MN, USA.
Keith M WirthDepartment of Surgery, University of Minnesota, MN, USA.
Scott Hunter OpplerDepartment of Surgery, University of Minnesota, MN, USA.
Laura Hocum StoneDepartment of Surgery, University of Minnesota, MN, USA.
Jody L JanecekDepartment of Surgery, University of Minnesota, MN, USA.
Adam C ShekaDepartment of Surgery, University of Minnesota, MN, USA.
Scott KizyDepartment of Surgery, University of Minnesota, MN, USA.
Meghan E G MooreDepartment of Surgery, University of Minnesota, MN, USA.
Christopher StaleyDepartment of Surgery, University of Minnesota, MN, USA.
Bernhard J HeringDepartment of Surgery, University of Minnesota, MN, USA.
Sabarinathan RamachandranDepartment of Surgery, University of Minnesota, MN, USA.
Sayeed IkramuddinDepartment of Surgery, University of Minnesota, MN, USA.
Melanie L GrahamDepartment of Surgery, University of Minnesota, MN, USA.
University of Minnesota · USBiotechnology Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The obesity epidemic significantly contributes to overall morbidity and mortality. Bariatric surgery is the gold standard treatment for obesity and metabolic dysfunction, yet the mechanisms by which it exerts metabolic benefit remain unclear. Here, we demonstrate a model of vertical sleeve gastrectomy (VSG) in nonhuman primates (NHP) that mimics the complexity and outcomes in humans. We also show that VSG confers weight loss and durable metabolic benefit, where equivalent caloric intake in shams resulted in significant weight gain following surgery. Furthermore, we show that VSG is associated with early, weight-independent increases in bile acids, short-chain fatty acids, and reduced visceral adipose tissue (VAT) inflammation with a polarization of VAT-resident immunocytes toward highly regulatory myeloid cells and Tregs. These data demonstrate that this strongly translational NHP model can be used to interrogate factors driving successful intervention to unravel the interplay between physiologic systems and improve therapies for obesity and metabolic syndrome.

Indexed as

ImmunologyObesity medicineSurgery

Identifiers

PMID34877488
PMCPMC8633018
OpenAlexW3213078755

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.