Evidence map›Paper›PMID 34878944›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2022

Lysyl oxidase regulation and protein aldehydes in the injured newborn lung.

Ying Zhong, Rose C Mahoney, Zehedina Khatun, Howard H Chen, Christopher T Nguyen, Peter Caravan, Jesse D Roberts

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ying ZhongCardiovascular Research Center of the General Medical Services, Massachusetts General Hospital, Boston, Massachusetts.
Rose C MahoneyCardiovascular Research Center of the General Medical Services, Massachusetts General Hospital, Boston, Massachusetts.
Zehedina KhatunHarvard Medical School, Harvard University, Cambridge, Massachusetts.
Howard H ChenHarvard Medical School, Harvard University, Cambridge, Massachusetts.
Christopher T NguyenCardiovascular Research Center of the General Medical Services, Massachusetts General Hospital, Boston, Massachusetts.
Peter CaravanHarvard Medical School, Harvard University, Cambridge, Massachusetts.ORCID 0000-0002-3179-6537
Jesse D RobertsCardiovascular Research Center of the General Medical Services, Massachusetts General Hospital, Boston, Massachusetts.ORCID 0000-0003-0271-275X
Harvard University · USMassachusetts General Hospital · US

Funding

Serial evaluation of cardioprotective effects of exercise training in heart failure using cardiac diffusion tensor MRIR01HL151704 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NGUYEN, CHRISTOPHER T · 2020 to 2024
$3.4M
Stress-rest calf muscle perfusion: a functional diagnostic test for peripheral arterial disease (PAD)R01HL135242 · NHLBI · UNIVERSITY OF UTAH · PI NATARAJAN, PRADEEP · 2017 to 2020
$2.8M
PET Imaging of Pulmonary FibrosisR01HL131907 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D, LANUTI, MICHAEL · 2016 to 2018
$2.3M
TGFB and Nitric Oxide Signaling in Pediatric Pulmonary Vascular DiseaseR01HL125715 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ROBERTS, JESSE D · 2015 to 2018
$1.7M
PET Imaging of Pulmonary FibrosisR01HL116315 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2012 to 2014
$1.3M
Multiplexed Molecular Imaging of Cell Death PathwaysR00HL121152 · NHLBI · TUFTS MEDICAL CENTER · PI CHEN, HOWARD H. · 2017 to 2019
$747k
Electronics Upgrade for 11.7 TS10OD025234 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2018 to 2018
$595k
TGFB AND PULMONARY ALDEHYDES IN NEWBORN LUNG INJURYR56HL147863 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ROBERTS, JESSE D · 2019 to 2019
$425k
HPLC-ICP-MS SystemS10OD010650 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2013 to 2013
$371k
Multiplexed Molecular Imaging of Cell Death PathwaysK99HL121152 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CHEN, HOWARD H. · 2014 to 2015
$298k
NHLBI NIH HHS K99 HL121152NHLBI NIH HHS R00 HL121152NHLBI NIH HHS R01 HL116315NHLBI NIH HHS R01 HL125715NHLBI NIH HHS R01 HL131907NHLBI NIH HHS R01 HL135242NHLBI NIH HHS R01 HL151704NHLBI NIH HHS R56 HL147863NIH HHS S10 OD010650NIH HHS S10 OD025234
6 · The paper itself

Abstract

During newborn lung injury, excessive activity of lysyl oxidases (LOXs) disrupts extracellular matrix (ECM) formation. Previous studies indicate that TGFβ activation in the O

Indexed as

AldehydesAnimalsAnimals, NewbornEmbryo, MammalianExtracellular MatrixFibroblastsGene Expression Regulation, EnzymologicLungLung InjuryMiceMice, Inbred C57BLMolecular ProbesNIH 3T3 CellsProtein-Lysine 6-OxidasePulmonary AlveoliSignal TransductionAldehydesMolecular ProbesProtein-Lysine 6-OxidaseSmad ProteinsTransforming Growth Factor betaaldehydesbronchopulmonary dysplasialysyl oxidasemolecular probeTGFβ

Identifiers

PMID34878944
PMCPMC8794022
OpenAlexW4200297842

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.