Evidence map›Paper›PMID 34878972›Full record

ArticleeLife2021

Nuclear NAD

David Sokolov, Emily R Sechrest, Yekai Wang, Connor Nevin, Jianhai Du, Saravanan Kolandaivelu

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Inhibitors of NADInternational journal of molecular sciences · 2024
    Review
  8. Expression of NMNAT1 in the photoreceptors is sufficient to preventMolecular therapy. Methods & clinical development · 2023
    Article
  9. Article
  10. Review
  11. Review
  12. Nuclear NADeLife · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

David SokolovDepartment of Ophthalmology and Visual Sciences, Eye Institute, One Medical Center Drive, West Virginia University, Morgantown, United States.ORCID 0000-0001-6774-4133
Emily R SechrestDepartment of Ophthalmology and Visual Sciences, Eye Institute, One Medical Center Drive, West Virginia University, Morgantown, United States.
Yekai WangDepartment of Ophthalmology and Visual Sciences, Eye Institute, One Medical Center Drive, West Virginia University, Morgantown, United States.
Connor NevinDepartment of Ophthalmology and Visual Sciences, Eye Institute, One Medical Center Drive, West Virginia University, Morgantown, United States.
Jianhai DuDepartment of Ophthalmology and Visual Sciences, Eye Institute, One Medical Center Drive, West Virginia University, Morgantown, United States.
Saravanan KolandaiveluDepartment of Ophthalmology and Visual Sciences, Eye Institute, One Medical Center Drive, West Virginia University, Morgantown, United States.ORCID 0000-0002-8552-7850
West Virginia University · US

Funding

Training in Cellular & Molecular BiologyT32GM136534 · NIGMS · UNIVERSITY OF WASHINGTON · PI Andrew Atwell Oberst, LARRY S ZWEIFEL · 2021 to 2026
$5.8M
Metabolic dysfunction from ECM remodeling in diseases of human RPER01EY034364 · NEI · UNIVERSITY OF WASHINGTON · PI Jennifer Rayming Chao, Jianhai Du · 2022 to 2026
$2.8M
Retinal Mitochondrial Metabolism in Alzheimer's DiseaseR01EY031324 · NEI · WEST VIRGINIA UNIVERSITY · PI DU, JIANHAI · 2021 to 2024
$2.0M
Proline metabolism in retinal healthR01EY032462 · NEI · WEST VIRGINIA UNIVERSITY · PI DU, JIANHAI · 2021 to 2025
$1.9M
Mechanisms Behind Retinal Photoreceptor Cells Outer Segment BiogenesisR01EY028959 · NEI · WEST VIRGINIA UNIVERSITY · PI KOLANDAIVELU, SARAVANAN · 2018 to 2022
$1.9M
NEI NIH HHS R01 EY028959NEI NIH HHS R01 EY031324NEI NIH HHS R01 EY032462NEI NIH HHS R01 EY034364NIGMS NIH HHS T32 GM136534NIH HHS RO1EY028959
6 · The paper itself

Abstract

Despite mounting evidence that the mammalian retina is exceptionally reliant on proper NAD

Indexed as

Gene DeletionAnimalsFemaleMaleMiceNicotinamide-Nucleotide AdenylyltransferasePhotoreceptor Cells, VertebrateRetinal DegenerationRetinal NeuronsNicotinamide-Nucleotide AdenylyltransferaseNmnat1 protein, mousedevelopmental biologymouseNADneuroscienceNMNAT1retinaretinal degenerationretinal developmentretinal metabolism

Identifiers

PMID34878972
PMCPMC8754432
OpenAlexW4200179753

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.