Evidence map›Paper›PMID 34879146›Full record

ReviewNutrition reviews2021

Cardiometabolic health benefits of dairy-milk polar lipids.

Richard S Bruno, Avinash Pokala, Moises Torres-Gonzalez, Christopher N Blesso

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrition reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03860584 (Alleviation Of Metabolic Endotoxemia In Adults With Metabolic Syndrome With Milk Fat Globule Membrane), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03860584 nacompletednot on this map

Alleviation Of Metabolic Endotoxemia In Adults With Metabolic Syndrome With Milk Fat Globule Membrane

TypeinterventionalSponsorOhio State UniversityRan2019 to 2020Enrolled30ConditionsMetabolic Syndrome, Metabolic EndotoxemiaArmsMFGM-enriched full-fat dairy milk, Soy phospholipid/lecithin milk
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Richard S BrunoHuman Nutrition Program, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-6772-2038
Avinash PokalaHuman Nutrition Program, The Ohio State University, Columbus, Ohio, USA.
Moises Torres-GonzalezNational Dairy Council, Rosemont, Illinois, USA.
Christopher N BlessoDepartment of Nutritional Sciences, University of Connecticut, Storrs, Connecticut, USA.
The Ohio State University · USDairy Management · USUniversity of Connecticut · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low-quality dietary patterns impair cardiometabolic health by increasing the risk of obesity-related disorders. Cardiometabolic risk relative to dairy-food consumption continues to be a controversial topic, due to recommendations that endorse low-fat and nonfat dairy foods over full-fat varieties despite accumulated evidence that does not strongly support these recommendations. Controlled human studies and mechanistic preclinical investigations support that full-fat dairy foods decrease cardiometabolic risk by promoting gut health, reducing inflammation, and managing dyslipidemia. These gut- and systemic-level cardiometabolic benefits are attributed, at least in part, to milk polar lipids (MPLs) derived from the phospholipid- and sphingolipid-rich milk fat globule membrane that is of higher abundance in full-fat dairy milk. The controversy surrounding full-fat dairy food consumption is discussed in this review relative to cardiometabolic health and MPL bioactivities that alleviate dyslipidemia, shift gut microbiota composition, and reduce inflammation. This summary, therefore, is expected to advance the understanding of full-fat dairy foods through their MPLs and the need for translational research to establish evidence-based dietary recommendations.

Indexed as

Cardiovascular DiseasesDyslipidemiasGastrointestinal MicrobiomeAnimalsDairy ProductsDiet, Fat-RestrictedHumansMilkdairy milkmilk fat globule membranemilk phospholipidsmilk polar lipidsmilk sphingomyelin

Identifiers

PMID34879146
PMCPMC8653938
OpenAlexW4200234457

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.