Evidence map›Paper›PMID 34879865›Full record

ArticleCell & bioscience2021

Intranasal HD-Ad vaccine protects the upper and lower respiratory tracts of hACE2 mice against SARS-CoV-2.

Huibi Cao, Juntao Mai, Zhichang Zhou, Zhijie Li, Rongqi Duan, Jacqueline Watt, Ziyan Chen, Ranmal Avinash Bandara, Ming Li, Sang Kyun Ahn and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell & bioscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

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  4. Developing the next-generation of adenoviral vector vaccines.Human vaccines & immunotherapeutics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 1 country.

Huibi Cao *Translational Medicine Program, Hospital for Sick Children Research Institute, Toronto, ON, Canada.
Juntao Mai *Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Zhichang Zhou *Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Zhijie LiDepartment of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Rongqi DuanTranslational Medicine Program, Hospital for Sick Children Research Institute, Toronto, ON, Canada.
Jacqueline WattDepartment of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Ziyan ChenTranslational Medicine Program, Hospital for Sick Children Research Institute, Toronto, ON, Canada.
Ranmal Avinash BandaraTranslational Medicine Program, Hospital for Sick Children Research Institute, Toronto, ON, Canada.
Ming LiDepartment of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Sang Kyun AhnDepartment of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Betty PoonCombined Containment Level 3 Unit, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Natasha Christie-HolmesCombined Containment Level 3 Unit, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Scott D Gray-OwenDepartment of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Arinjay BanerjeeVaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK, Canada.
Karen MossmanDepartment of Medicine Institute for Infectious Disease Research, McMaster Immunology Research Center, McMaster University, Hamilton, ON, Canada.
Rob KozakSunnybrook Heath Sciences Centre, Toronto, ON, Canada.
Samira MubarekaSunnybrook Heath Sciences Centre, Toronto, ON, Canada.
James M RiniDepartment of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada. james.rini@utoronto.ca.
Jim HuTranslational Medicine Program, Hospital for Sick Children Research Institute, Toronto, ON, Canada. jim.hu@sickkids.ca.
Jun LiuDepartment of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada. jun.liu@utoronto.ca.ORCID http://orcid.org/0000-0002-0522-6733
University of Toronto · CAHospital for Sick Children · CASunnybrook Health Science Centre · CAMcMaster University · CAUniversity of Waterloo · CA

Funding

CIHR VR1-172771CIHR VS-1-17553138
6 · The paper itself

Abstract

backgroundThe ongoing COVID-19 pandemic has resulted in 185 million recorded cases and over 4 million deaths worldwide. Several COVID-19 vaccines have been approved for emergency use in humans and are being used in many countries. However, all the approved vaccines are administered by intramuscular injection and this may not prevent upper airway infection or viral transmission.

resultsHere, we describe a novel, intranasally delivered COVID-19 vaccine based on a helper-dependent adenoviral (HD-Ad) vector. The vaccine (HD-Ad_RBD) produces a soluble secreted form of the receptor binding domain (RBD) of the SARS-CoV-2 spike protein and we show it induced robust mucosal and systemic immunity. Moreover, intranasal immunization of K18-hACE2 mice with HD-Ad_RBD using a prime-boost regimen, resulted in complete protection of the upper respiratory tract against SARS-CoV-2 infection.

conclusionOur approaches provide a powerful platform for constructing highly effective vaccines targeting SARS-CoV-2 and its emerging variants.

Indexed as

COVID-19HD-AdNasal deliverySARS-CoV2Vaccine

Identifiers

PMID34879865
PMCPMC8653804
OpenAlexW4225699254

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.