Evidence map›Paper›PMID 34880866›Full record

ArticleFrontiers in immunology2021

High-Resolution, 3D Imaging of the Zebrafish Gill-Associated Lymphoid Tissue (GIALT) Reveals a Novel Lymphoid Structure, the Amphibranchial Lymphoid Tissue.

Alf S Dalum, Aurora Kraus, Shanawaz Khan, Erna Davydova, Dimitri Rigaudeau, Håvard Bjørgen, Adrián López-Porras, Gareth Griffiths, Geert F Wiegertjes, Erling O Koppang and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Chromosome-scale genome of European anchovy (Engraulis encrasicolus L., 1758) and comparative genomics uncover clupeid-specific immune gene expansions.DNA research : an international journal for rapid publication of reports on genes and genomes · 2026
    Article
  3. Article
  4. Zebrafish as a Model for Translational Immuno-Oncology.Journal of personalized medicine · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. A tessellated lymphoid network provides whole-body T cell surveillance in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 4 countries.

Alf S DalumNofima, Norwegian Institute of Food, Fisheries and Aquaculture Research, Ås, Norway.
Aurora KrausCenter for Evolutionary and Theoretical Immunology (CETI), Department of Biology, University of New Mexico, Albuquerque, NM, United States.
Shanawaz KhanDepartment of Biosciences, FYSCELL, University of Oslo, Oslo, Norway.
Erna DavydovaDepartment of Biosciences, BMB, University of Oslo, Oslo, Norway.
Dimitri RigaudeauINRAE, IERP, Université Paris-Saclay, Jouy-en-Josas, France.
Håvard BjørgenSection of Anatomy, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Ås, Norway.
Adrián López-PorrasDepartment of Biosciences, FYSCELL, University of Oslo, Oslo, Norway.
Gareth GriffithsDepartment of Biosciences, FYSCELL, University of Oslo, Oslo, Norway.
Geert F WiegertjesAquaculture and Fisheries Group, Department of Animal Sciences, Wageningen University & Research, Wageningen, Netherlands.
Erling O KoppangSection of Anatomy, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Ås, Norway.
Irene SalinasCenter for Evolutionary and Theoretical Immunology (CETI), Department of Biology, University of New Mexico, Albuquerque, NM, United States.
Pierre BoudinotINRAE, UVSQ, VIM, Université Paris-Saclay, Jouy-en-Josas, France.
Julien RességuierDepartment of Biosciences, FYSCELL, University of Oslo, Oslo, Norway.
University of Oslo · NONorwegian University of Life Sciences · NOUniversity of New Mexico · USNofima · NOUniversité de Versailles Saint-Quentin-en-Yvelines · FRUniversité Paris-Saclay · FRWageningen University & Research · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The zebrafish is extensively used as an animal model for human and fish diseases. However, our understanding of the structural organization of its immune system remains incomplete, especially the mucosa-associated lymphoid tissues (MALTs). Teleost MALTs are commonly perceived as diffuse and scattered populations of immune cells throughout the mucosa. Yet, structured MALTs have been recently discovered in Atlantic salmon (

Indexed as

AnimalsFish DiseasesGillsImaging, Three-DimensionalLymphoid TissueViremiaZebrafishALTGIALTgillsILTimmunologylymphoid tissuemucosal immunityzebrafish

Identifiers

PMID34880866
PMCPMC8647647
OpenAlexW3212113656

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.