ReviewAgeing research reviews2022
The accelerated aging phenotype: The role of race and social determinants of health on aging.
Review in Ageing research reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
114 citing papers in PubMed, 160 citations in OpenAlex.
- Unfavorable Social Determinants of Health Are Associated with Lower Cognitive Performance in Non-Hispanic Black Men - The HABS-HD Study.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2026Article
- Association of mitochondrial DNA haplogroup, oxidative DNA damage and inflammatory markers in middle-aged adults.International journal of radiation biology · 2026Article
- Frailty Transforms Care Continuity-Mortality Relationships Across Age Groups: Evidence From Taiwan and South Korea.Journal of cachexia, sarcopenia and muscle · 2026Article
- Longitudinal analysis of cytokines, chemokines, and inflammatory markers in a middle-aged cohort.GeroScience · 2026Article
- Associations of psychosocial factors with cardiovascular health in aging: insights from the Inlife-Aging Project.GeroScience · 2026Article
- Phenotypic age acceleration and all-cause and cardiovascular mortality among U.S. adults at risk for heart failure.American heart journal plus : cardiology research and practice · 2026Article
- Developmental Associations of Racialized Experiences and Attitudes in the 20s with Health Status Approaching Midlife.Journal of racial and ethnic health disparities · 2026Article
- An evaluation of the impact of visual attributes of park landscape spaces on the emotional benefits and behavioral intention of younger older adults.Scientific reports · 2026Article
- Accelerated metabolomic aging and its association with social determinants of health in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Discrimination and Multimorbidity Among Older Adults.Journal of racial and ethnic health disparities · 2026Article
- Older Age Is Associated With Long-Term Retention in Buprenorphine Treatment for Opioid Use Disorder.Journal of the American Geriatrics Society · 2026Article
- Multi-system aging vulnerability associated with prolonged violence exposure: evidence from a Colombian sample.Frontiers in human neuroscience · 2026Article
- Factors Associated With Physiological Dysregulation Among US Adults Aged 45 Years and Older: A Nationally Representative Study.Journal of aging research · 2026Article
- Article
- Klotho levels and biological age acceleration: Insights from a diverse cohort of middle-aged and elderly individuals.PloS one · 2026Article
- Association between anxiety and sleep disorders in older adults: evidence from the 2020 health and retirement study.Frontiers in psychology · 2026Article
- Predictors and Consequences of Poor Health Trajectories Among US Adults Ages 50-64: A Latent Class Growth Analysis.Journal of general internal medicine · 2026Article
- Application of artificial intelligence in geriatric infection: recent advances and prospects.Frontiers in cellular and infection microbiology · 2026Review
- Integrating epidemiological and bioinformatics analyses identified the effects of organophosphate pesticides accelerating biological aging.International journal of surgery (London, England) · 2025Article
- Development of a Mortality Prediction Model for Incarcerated Adults to Identify Palliative Care Needs.Journal of general internal medicine · 2025Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The pursuit to discover the fundamental biology and mechanisms of aging within the context of the physical and social environment is critical to designing interventions to prevent and treat its complex phenotypes. Aging research is critically linked to understanding health disparities because these inequities shape minority aging, which may proceed on a different trajectory than the overall population. Health disparities are characteristically seen in commonly occurring age-associated diseases such as cardiovascular and cerebrovascular disease as well as diabetes mellitus and cancer. The early appearance and increased severity of age-associated disease among African American and low socioeconomic status (SES) individuals suggests that the factors contributing to the emergence of health disparities may also induce a phenotype of 'premature aging' or 'accelerated aging' or 'weathering'. In marginalized and low SES populations with high rates of early onset age-associated disease the interaction of biologic, psychosocial, socioeconomic and environmental factors may result in a phenotype of accelerated aging biologically similar to premature aging syndromes with increased susceptibility to oxidative stress, premature accumulation of oxidative DNA damage, defects in DNA repair and higher levels of biomarkers of oxidative stress and inflammation. Health disparities, therefore, may be the end product of this complex interaction in populations at high risk. This review will examine the factors that drive both health disparities and the accelerated aging phenotype that ultimately contributes to premature mortality.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.