Evidence map›Paper›PMID 34885960›Full record

ArticleMolecules (Basel, Switzerland)2021

Modulating Properties of Piroxicam, Meloxicam and Oxicam Analogues against Macrophage-Associated Chemokines in Colorectal Cancer.

Paulina Lewandowska, Izabela Szczuka, Iwona Bednarz-Misa, Berenika M Szczęśniak-Sięga, Katarzyna Neubauer, Magdalena Mierzchała-Pasierb, Marek Zawadzki, Wojciech Witkiewicz, Małgorzata Krzystek-Korpacka

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Paulina LewandowskaDepartment of Biochemistry and Immunochemistry, Wroclaw Medical University, 50-368 Wroclaw, Poland.
Izabela SzczukaDepartment of Biochemistry and Immunochemistry, Wroclaw Medical University, 50-368 Wroclaw, Poland.ORCID 0000-0001-7311-9633
Iwona Bednarz-MisaDepartment of Biochemistry and Immunochemistry, Wroclaw Medical University, 50-368 Wroclaw, Poland.ORCID 0000-0001-7244-2017
Berenika M Szczęśniak-SięgaDepartment of Medicinal Chemistry, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland.ORCID 0000-0003-3770-5760
Katarzyna NeubauerDepartment and Clinics of Gastroenterology and Hepatology, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Magdalena Mierzchała-PasierbDepartment of Biochemistry and Immunochemistry, Wroclaw Medical University, 50-368 Wroclaw, Poland.ORCID 0000-0001-9640-4883
Marek ZawadzkiDepartment of Oncological Surgery, Regional Specialist Hospital, 51-124 Wroclaw, Poland.
Wojciech WitkiewiczDepartment of Oncological Surgery, Regional Specialist Hospital, 51-124 Wroclaw, Poland.
Małgorzata Krzystek-KorpackaDepartment of Biochemistry and Immunochemistry, Wroclaw Medical University, 50-368 Wroclaw, Poland.ORCID 0000-0002-2753-8092
Wroclaw Medical University · PLWroclaw Research Centre EIT+ (Poland) · PL

Funding

the European Regional Development Fund WroVasc - Integrated Cardiovascular CentreWrocław Medical University statutory research funding SUB.A040.21.012
6 · The paper itself

Abstract

The mechanisms underlying the antineoplastic effects of oxicams have not been fully elucidated. We aimed to assess the effect of classic and novel oxicams on the expression/secretion of macrophage-associated chemokines (RTqPCR/Luminex xMAP) in colorectal adenocarcinoma cells, and on the expression of upstream the non-steroidal anti-inflammatory drug (NSAID)-activated genes

Indexed as

AgedAnti-Inflammatory Agents, Non-SteroidalAntineoplastic AgentsCaco-2 CellsChemokinesColorectal NeoplasmsFemaleHCT116 CellsHumansMacrophagesMaleMeloxicamPiroxicamAnti-Inflammatory Agents, Non-SteroidalAntineoplastic AgentsChemokinesMeloxicamPiroxicamcancer-related inflammationdrug repurposinggrowth differentiation factor 15 (GDF-15)immunotherapymacrophage inflammatory protein (MIP)macrophage inhibitory cytokine 1 (MIC-1)meloxicammonocyte chemoattractant protein (MCP)non-steroidal anti-inflammatory drugs (NSAIDs)piroxicam

Identifiers

PMID34885960
PMCPMC8659253
OpenAlexW4200272769

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.