Evidence map›Paper›PMID 34887873›Full record

ArticleFrontiers in immunology2021

A Novel Germline Heterozygous

Henry Y Lu, Robert Sertori, Alejandra V Contreras, Mark Hamer, Melina Messing, Kate L Del Bel, Elena Lopez-Rangel, Edmond S Chan, Wingfield Rehmus, Joshua D Milner and 4 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. BCL11B-related disease: a single phenotypic entity?European journal of human genetics : EJHG · 2025
    Pooled it
  2. Article
  3. Article
  4. Article
  5. [BCL11B associated disorder a case report in Mexican population. Case report].Revista medica del Instituto Mexicano del Seguro Social · 2024
    Article
  6. Review
  7. Review
  8. A Bcl11bFrontiers in immunology · 2024
    Article
  9. Article
  10. Review
  11. Biological treatment for bullous pemphigoid.Frontiers in immunology · 2023
    Article
  12. Article
  13. Case report: A novel truncating variant ofFrontiers in pediatrics · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Henry Y LuDepartment of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, BC, Canada.
Robert SertoriBlood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, United States.
Alejandra V ContrerasBlood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, United States.
Mark HamerBiomedical Research Centre, The University of British Columbia, Vancouver, BC, Canada.
Melina MessingExperimental Medicine Program, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.
Kate L Del BelDepartment of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, BC, Canada.
Elena Lopez-RangelDepartment of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, BC, Canada.
Edmond S ChanDepartment of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, BC, Canada.
Wingfield RehmusDepartment of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, BC, Canada.
Joshua D MilnerDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY, United States.
Kelly M McNagnyBiomedical Research Centre, The University of British Columbia, Vancouver, BC, Canada.
Anna LehmanDepartment of Medical Genetics, The University of British Columbia, Vancouver, BC, Canada.
David L WiestBlood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, United States.
Stuart E TurveyDepartment of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, BC, Canada.
University of British Columbia · CAFox Chase Cancer Center · USBC Children's Hospital · CAColumbia University Irving Medical Center · US

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Eric Andrew Ross · 1985 to 2026
$138.8M
Inherited T cell defects: Diagnosis, Mechanisms and TreatmentsP01AI138962 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARSON, ALEXANDER · 2020 to 2024
$11.3M
CIHRNCI NIH HHS P30 CA006927NIAID NIH HHS P01 AI138962
6 · The paper itself

Abstract

B-cell lymphoma/leukemia 11B (BCL11B) is a C

Indexed as

Germ-Line MutationAdolescentAnimalsDNA Mutational AnalysisFemaleGenetic Predisposition to DiseaseHeterozygoteHumansHypersensitivityPhenotypePrimary Immunodeficiency DiseasesRepressor ProteinsSeverity of Illness IndexT-LymphocytesTumor Suppressor ProteinsZebrafishBCL11B protein, humanRepressor ProteinsTumor Suppressor ProteinsZebrafish ProteinsBCL11Bhyper IgEinborn errors of immunityprimary atopic disordersprimary immunodeficiencies

Identifiers

PMID34887873
PMCPMC8650153
OpenAlexW3215745081

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.