Evidence map›Paper›PMID 34888403›Full record

ArticleOpen forum infectious diseases2021

Identification of Risk Factors for Daptomycin-Associated Creatine Phosphokinase Elevation and Development of a Risk Prediction Model for Incidence Probability.

Masaru Samura, Naoki Hirose, Takenori Kurata, Keisuke Takada, Fumio Nagumo, Sakura Koshioka, Junichi Ishii, Masaki Uchida, Junki Inoue, Yuki Enoki and 5 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Pharmacist-driven antimicrobial stewardship: evolving roles in clinical practice.Journal of pharmaceutical health care and sciences · 2026
    Review
  2. Article
  3. Article
  4. Risk factors of daptomycin overexposure: a case-control study.Antimicrobial agents and chemotherapy · 2025
    Article
  5. Observational
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Masaru SamuraDivision of Pharmacodynamics, Keio University Faculty of Pharmacy, Tokyo, Japan.
Naoki HiroseDepartment of Pharmacy, Yokohama General Hospital, Kanagawa, Japan.
Takenori KurataDepartment of Pharmacy, Yokohama General Hospital, Kanagawa, Japan.
Keisuke TakadaDepartment of Pharmacy, Yokohama General Hospital, Kanagawa, Japan.
Fumio NagumoDepartment of Pharmacy, Yokohama General Hospital, Kanagawa, Japan.
Sakura KoshiokaDepartment of Pharmacy, Yokohama General Hospital, Kanagawa, Japan.
Junichi IshiiDepartment of Pharmacy, Yokohama General Hospital, Kanagawa, Japan.
Masaki UchidaDepartment of Pharmacy, Yokohama General Hospital, Kanagawa, Japan.
Junki InoueDepartment of Pharmacy, Yokohama General Hospital, Kanagawa, Japan.
Yuki EnokiDivision of Pharmacodynamics, Keio University Faculty of Pharmacy, Tokyo, Japan.ORCID https://orcid.org/0000-0002-5934-0670
Kazuaki TaguchiDivision of Pharmacodynamics, Keio University Faculty of Pharmacy, Tokyo, Japan.ORCID https://orcid.org/0000-0002-3575-0448
Ryuji HigashitaWound Care Center, Yokohama General Hospital, Kanagawa, Japan.
Norifumi KunikaInternal Medicine, Yokohama General Hospital, Kanagawa, Japan.
Koji TanikawaDepartment of Pharmacy, Yokohama General Hospital, Kanagawa, Japan.
Kazuaki MatsumotoDivision of Pharmacodynamics, Keio University Faculty of Pharmacy, Tokyo, Japan.
Yokohama University of Pharmacy · JPKeio University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn this study, we investigated the risk factors for daptomycin-associated creatine phosphokinase (CPK) elevation and established a risk score for CPK elevation.

methodsPatients who received daptomycin at our hospital were classified into the non-elevated or elevated CPK group based on their peak CPK levels during daptomycin therapy. Univariable and multivariable analyses were performed, and a risk score and prediction model for the incidence probability of CPK elevation were calculated based on logistic regression analysis.

resultsThe non-elevated and elevated CPK groups included 181 and 17 patients, respectively. Logistic regression analysis revealed that concomitant statin use (odds ratio [OR], 4.45 [95% confidence interval {CI}, 1.40-14.47]; risk score 4), concomitant antihistamine use (OR, 5.66 [95% CI, 1.58-20.75]; risk score 4), and trough concentration (C

conclusionsThese results suggested that concomitant use of statins with antihistamines and C

Indexed as

creatine phosphokinasedaptomycinincidence prediction modelrisk factorrisk scoretrough concentration

Identifiers

PMID34888403
PMCPMC8651170
OpenAlexW3211426515

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.