Evidence map›Paper›PMID 34888938›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2022

Antioxidant enzyme peroxiredoxin 5 regulates cyst growth and ciliogenesis via modulating Plk1 stability.

Ewud Agborbesong, Julie Xia Zhou, Linda Xiaoyan Li, James P Calvet, Xiaogang Li

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ewud AgborbesongDepartment of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Julie Xia ZhouDepartment of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Linda Xiaoyan LiDepartment of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
James P CalvetDepartment of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Xiaogang LiDepartment of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Mayo Clinic · USUniversity of Kansas Medical Center · US

Funding

Polycystin Function Resource Development CoreU54DK126126 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Alan S Yu · 2020 to 2026
$5.8M
Pilot and Feasibility CoreP30DK106912 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI CALVET, JAMES P · 2015 to 2019
$5.5M
The crosstalk of DNA and lysine methyltransferases in ADPKD.R01DK126662 · NIDDK · MAYO CLINIC ROCHESTER · PI Xiaogang Li · 2020 to 2026
$3.0M
ADPKD: Understanding immunosuppression mechanisms and discovering treatmentR01DK129241 · NIDDK · MAYO CLINIC ROCHESTER · PI LI, XIAOGANG · 2021 to 2024
$1.8M
NIDDK NIH HHS P30 DK106912NIDDK NIH HHS R01 DK126662NIDDK NIH HHS R01 DK129241NIDDK NIH HHS U54 DK126126
6 · The paper itself

Abstract

Oxidative stress is emerging as a contributing factor to the homeostasis in cystic diseases. However, the role antioxidant enzymes play in the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD) remains elusive. Peroxiredoxin 5 (Prdx5) is an antioxidant enzyme that catalyzes the reduction of H

Indexed as

AnimalsAntioxidantsCell Cycle ProteinsCell LineCiliaEnzyme StabilityHumansKidneyMiceMice, KnockoutOxidative StressPeroxiredoxinsPolo-Like Kinase 1Polycystic Kidney, Autosomal DominantProtein Serine-Threonine KinasesProto-Oncogene ProteinsAntioxidantsCell Cycle ProteinsPeroxiredoxinsPolo-Like Kinase 1PRDX5 protein, humanPrdx5 protein, mouseProtein Serine-Threonine KinasesProto-Oncogene ProteinsADPKDciliogenesiscyst growthperoxiredoxin 5Plk1

Identifiers

PMID34888938
PMCPMC9060392
OpenAlexW4200184436

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.