Evidence map›Paper›PMID 34894846›Full record

ArticleMolecular pain

Endothelin receptor type A is involved in the development of oxaliplatin-induced mechanical allodynia and cold allodynia acting through spinal and peripheral mechanisms in rats.

Kae Matsuura, Atsushi Sakai, Yuji Watanabe, Yasunori Mikahara, Atsuhiro Sakamoto, Hidenori Suzuki

Open access · goldAbstract read
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kae MatsuuraDepartment of Anesthesiology, 26367Nippon Medical School, Bunkyo-ku, Japan.
Atsushi SakaiDepartment of Pharmacology, 26367Nippon Medical School, Bunkyo-ku, Japan.ORCID 0000-0002-3996-8022
Yuji WatanabeDepartment of Pharmacology, 26367Nippon Medical School, Bunkyo-ku, Japan.
Yasunori MikaharaDepartment of Pharmacology, 26367Nippon Medical School, Bunkyo-ku, Japan.
Atsuhiro SakamotoDepartment of Anesthesiology, 26367Nippon Medical School, Bunkyo-ku, Japan.
Hidenori SuzukiDepartment of Pharmacology, 26367Nippon Medical School, Bunkyo-ku, Japan.ORCID 0000-0002-7133-4302
Nippon Medical School · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxaliplatin, a platinum-based chemotherapeutic agent, frequently causes severe neuropathic pain typically encompassing cold allodynia and long-lasting mechanical allodynia. Endothelin has been shown to modulate nociceptive transmission in a variety of pain disorders. However, the action of endothelin varies greatly depending on many variables, including pain causes, receptor types (endothelin type A (ET

Indexed as

HyperalgesiaNeuralgiaReceptor, Endothelin AAnimalsOxaliplatinRatsRats, Sprague-DawleyOxaliplatinReceptor, Endothelin AET-1ET receptorneuropathic painperipheryspinal cord

Identifiers

PMID34894846
PMCPMC8679041
OpenAlexW4200550100

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.