Evidence map›Paper›PMID 34895998›Full record

Trial reportNutrition, metabolism, and cardiovascular diseases : NMCD2022

Effects of a diet based on the Dietary Guidelines on vascular health and TMAO in women with cardiometabolic risk factors.

Sridevi Krishnan, Erik R Gertz, Sean H Adams, John W Newman, Theresa L Pedersen, Nancy L Keim, Brian J Bennett

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrition, metabolism, and cardiovascular diseases : NMCD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02298725 (Individual Metabolism and Physiology Signature Study), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02298725 nacompletednot on this map

Individual Metabolism and Physiology Signature Study

TypeinterventionalSponsorUSDA, Western Human Nutrition Research CenterRan2014 to 2017Enrolled52ConditionsInsulin Resistance, Metabolic Syndrome X, ObesityArmsDGA Diet Plan, NHANES Diet Plan
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sridevi KrishnanUSDA-Western Human Nutrition Research Center, Davis, CA, USA; Department of Nutrition, University of California-Davis, Davis, CA, USA.
Erik R GertzUSDA-Western Human Nutrition Research Center, Davis, CA, USA.
Sean H AdamsDepartment of Surgery, University of California Davis School of Medicine, Sacramento, CA, USA; Center for Alimentary and Metabolic Science, University of California Davis School of Medicine, Sacramento, CA, USA.
John W NewmanUSDA-Western Human Nutrition Research Center, Davis, CA, USA; Department of Nutrition, University of California-Davis, Davis, CA, USA.
Theresa L PedersenDepartment of Food Science and Technology, University of California-Davis, Davis, CA, USA.
Nancy L KeimUSDA-Western Human Nutrition Research Center, Davis, CA, USA; Department of Nutrition, University of California-Davis, Davis, CA, USA.
Brian J BennettUSDA-Western Human Nutrition Research Center, Davis, CA, USA; Department of Nutrition, University of California-Davis, Davis, CA, USA. Electronic address: brian.bennett@usda.gov.
Western Human Nutrition Research Center · USUniversity of California, Davis · US

Funding

NHLBI NIH HHS R01 HL128572NHLBI NIH HHS R01 HL148110
6 · The paper itself

Abstract

BACKGROUND AND

aimsRecent evidence links trimethylamine oxide (TMAO) to endothelial dysfunction, an early indicator of cardiovascular disease. We aimed to determine whether short-term consumption of a diet patterned after the 2010 Dietary Guidelines for Americans (DGA) would affect endothelial function, plasma TMAO concentrations, and cardiovascular disease risk, differently than a typical American Diet (TAD). METHODS AND

resultsAn 8-wk controlled feeding trial was conducted in overweight/obese women pre-screened for insulin resistance and/or dyslipidemia. Women were randomized to a DGA or TAD group (n = 22/group). At wk0 (pre-intervention) and wk8 (post-intervention) vascular age was calculated; endothelial function (reactive hyperemia index (RHI)) and augmentation index (AI@75) were measured using EndoPAT, and plasma TMAO was measured by LC-MS/MS. Vascular age was reduced in DGA at wk8 compared to wk0 but TAD wk8 was not different from wk0 (DGA wk0: 54.2 ± 4.0 vs. wk8: 50.5 ± 3.1 (p = 0.05), vs. TAD wk8: 47.7 ± 2.3). Plasma TMAO concentrations, RHI, and AI@75 were not different between groups or weeks.

conclusionConsumption of a diet based on the 2010 Dietary Guidelines for Americans for 8 weeks did not improve endothelial function or reduce plasma TMAO. CLINICALTRIALS.GOV: NCT02298725.

Indexed as

Cardiometabolic Risk FactorsDietChromatography, LiquidFemaleHumansMethylaminesNutrition PolicyObesityOverweightTandem Mass SpectrometryUnited StatesMethylaminestrimethyloxamineControlled feeding trialDietary guidelines diet patternEndothelial dysfunction

Identifiers

PMID34895998
PMCPMC8798222
OpenAlexW3199988729

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.