ArticleBone2022
Bisphosphonates: The role of chemistry in understanding their biological actions and structure-activity relationships, and new directions for their therapeutic use.
Open access · greenAbstract read
In one paragraph
Article in Bone, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.6field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 83 citations in OpenAlex.
- Modern pharmacological management of Osteoporosis: from monotherapy to sequential and combination approaches in postmenopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Review
- Parenteral Ozone Therapy Combined with Topical Antimicrobials Enhances Tissue Repair in Mandibular Osteonecrosis of Elderly Female Rats.Journal of functional biomaterials · 2026Article
- Multiomic profiling of responses to clinical and novel bisphosphonates reveals extraskeletal effects on ageing related signatures.Signal transduction and targeted therapy · 2026Article
- Nanoparticle Strategies for Bone Metastasis Immunotherapy: Targeting, Immune Reprogramming and Combination Therapy.Pharmaceutics · 2026Review
- Hesperetin modulates osteoprogenitor cells and macrophages under zoledronic acid and inflammatory stress.Archives of oral biology · 2026Article
- The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches.Medicinal research reviews · 2026Review
- Rescuing Mitochondrial Dysfunction in Macrophages Prevents Osteonecrosis of the Jaw in Anti-Resorptive Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Targeted drug repurposing in medication-related osteonecrosis of the jaw: a review of teriparatide and pentoxifylline/α-tocopherol protocols.Frontiers in medicine · 2026Review
- Effectiveness and safety of neridronate in chronic nonbacterial osteomyelitis: insight from the CAMELOT registry.Therapeutic advances in musculoskeletal disease · 2026Article
- Sulfated chitosan enhances BMP-2-mediated spinal fusion via skeletal stem cell rejuvenation in aging.Bioactive materials · 2025Article
- Recent advances in natural and synthetic phosphonate therapeutics.Current opinion in microbiology · 2025Review
- Article
- Immunological enhancement of micro-nanoparticle formulated with risedronate and zinc as vaccine adjuvant in aged mice.Immunity & ageing : I & A · 2025Article
- First-in-human study of dosimetry, safety and efficacy for [European journal of nuclear medicine and molecular imaging · 2025Article
- Geranylgeranyl diphosphate synthase inhibition impairs osteoclast differentiation, morphology, and resorptive activity.JBMR plus · 2025Article
- Characterization and preparation of food-derived peptides on improving osteoporosis: A review.Food chemistry: X · 2024Article
- An improved understanding of pediatric chronic nonbacterial osteomyelitis pathophysiology informs current and future treatment.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Review
- Nitrogen-containing bisphosphonate induces enhancement of OPG expression and inhibition of RANKL expression via inhibition of farnesyl pyrophosphate synthase to inhibit the osteogenic differentiation and calcification in vascular smooth muscle cells.BMC cardiovascular disorders · 2024Article
- Article
- Hydroxychloroquine and a low activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects.Research square · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 7 institutions in 2 countries.
Frank H EbetinoBioVinc LLC, 2265 E. Foothill Blvd, Pasadena, CA 91107, USA; Department of Chemistry, University of Rochester, Rochester, NY 14617, USA; Department of Oncology & Metabolism, University of Sheffield, Sheffield, UK. Electronic address: halebetino@biovinc.com.
Shuting SunBioVinc LLC, 2265 E. Foothill Blvd, Pasadena, CA 91107, USA. Electronic address: shuting.sun@biovinc.com.
Philip CherianBioVinc LLC, 2265 E. Foothill Blvd, Pasadena, CA 91107, USA.
Sahar RoshandelBioVinc LLC, 2265 E. Foothill Blvd, Pasadena, CA 91107, USA.
Jeffrey D NeighborsPennsylvania State University, Hershey, PA, USA.
Eric HuBioVinc LLC, 2265 E. Foothill Blvd, Pasadena, CA 91107, USA.
James E DunfordNuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences, The Oxford University Institute of Musculoskeletal Sciences, The Botnar Research Centre, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.
Parish P SedghizadehHerman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90089, USA.
Charles E McKennaDepartment of Chemistry, University of Southern California, Los Angeles, CA 90089, USA.
Venkat SrinivasanDepartment of Chemistry, University of Rochester, Rochester, NY 14617, USA.
Robert K BoeckmanDepartment of Chemistry, University of Rochester, Rochester, NY 14617, USA.
R Graham G RussellDepartment of Oncology & Metabolism, University of Sheffield, Sheffield, UK; Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences, The Oxford University Institute of Musculoskeletal Sciences, The Botnar Research Centre, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK; Mellanby Centre for Musculoskeletal Research, University of Sheffield, Sheffield, UK.
BioVinc (United States) · USUniversity of Rochester · USUniversity of Southern California · USNuffield Orthopaedic Centre · GBPennsylvania State University · USUniversity of Oxford · GBUniversity of Sheffield · GB
Funding
Bone targeted delivery of an antimicrobial drug for osteomyelitis therapyR44AI125060 · NIAID · BIOVINC, LLC · PI EBETINO, FRANK H. · 2020 to 2022
$3.0MCompetitive Equilibrium-based Displacement of Bisphosphonates as Novel Therapeutic Approach for BRONJR44DE025524 · NIDCR · BIOVINC, LLC · PI EBETINO, FRANK H. · 2017 to 2018
$2.2MBone targeted antimicrobials for biofilm-mediated osteolytic infection treatmentR42DE025789 · NIDCR · BIOVINC, LLC · PI EBETINO, FRANK H., SEDGHIZADEH, PARISH PAYMON · 2017 to 2018
$1.5MBone Metastasis Specific 18F PET Imaging Probe for Breast CancerR41CA235996 · NCI · BIOVINC, LLC · PI CHEN, KAI, EBETINO, FRANK H. · 2019 to 2019
$225kBone targeted antimicrobials for the treatment of diabetic foot related infections and osteomyelitisR43AR073727 · NIAMS · BIOVINC, LLC · PI EBETINO, FRANK H. · 2018 to 2018
$225kNCI NIH HHS R41 CA235996NIAID NIH HHS R44 AI125060NIAMS NIH HHS R43 AR073727NIDCR NIH HHS R42 DE025789NIDCR NIH HHS R44 DE025524
Abstract
The bisphosphonates ((HO)
Indexed as
Bone NeoplasmsDiphosphonatesHumansMevalonic AcidNitrogenStructure-Activity RelationshipDiphosphonatesMevalonic AcidNitrogenBisphosphonatesBone resorptionBone targetingFarnesyl diphosphate synthase (FDPS/FPPS)HydroxyapatiteOsteoclasts
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.