Evidence map›Paper›PMID 34898382›Full record

ArticleBioengineered2022

Application of serum exosomal hypoxia-inducible factor-1 alpha (HIF-1α) as potential circulating biomarker for bacterial peritonitis.

Xiao-Yi Chen, Qian-Long Wang, Wei-Xue Huang, Long-Wei Li, Lan-Cong Liu, Yi Yang, You-Jiao Wu, Shan-Shan Song, Hao Ma, Hua Zhou and 1 more

Open access · goldAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineered, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Xiao-Yi ChenState Key Laboratories for Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
Qian-Long WangState Key Laboratories for Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
Wei-Xue HuangState Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Long-Wei LiState Key Laboratories for Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
Lan-Cong LiuState Key Laboratories for Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
Yi YangState Key Laboratories for Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
You-Jiao WuState Key Laboratories for Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
Shan-Shan SongState Key Laboratories for Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
Hao MaState Key Laboratories for Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
Hua ZhouState Key Laboratories for Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
Pei LuoState Key Laboratories for Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
Macau University of Science and Technology · MOChinese Academy of Sciences · CNTsinghua University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial peritonitis is a severe disease that diagnosis remains challenging for clinicians. Measuring biomarkers might be a rapid diagnostic method. The objective of this study was to analyze and evaluate the dynamic changes in HIF-1α concentration in serum exosomes during bacterial peritonitis. The pre-clinical application value of serum exosomal HIF-1α was evaluated via imipenem and cilastatin sodium (ICS) intervention in the bacterial peritonitis model. The new colorimetric method to quantitate dynamic expression changes of HIF-1α in serum exosomes during bacterial peritonitis was established by our team via using the gold seed-coated with aptamer-functionalized Au @ Au core-shell peroxidase mimic. The typical inflammatory cytokines of bacterial peritonitis were also measured. Following intramuscular administration with ICS,

Indexed as

AnimalsBacterial InfectionsBiomarkersFemaleHypoxia-Inducible Factor 1, alpha SubunitMaleMiceMice, Inbred BALB CPeritonitisRatsRats, Sprague-DawleyBiomarkersHif1a protein, mouseHif1a protein, ratHypoxia-Inducible Factor 1, alpha SubunitBacterial peritonitisbiomarkerexosomeHIF-1αhypoxia

Identifiers

PMID34898382
PMCPMC8973742
OpenAlexW4200522061

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.