Evidence map›Paper›PMID 34900173›Full record

ArticleJournal of healthcare engineering2021

Zhitao Jiang, Yi Han, Yuechan Zhang, Jie Li, Chundi Liu

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in Journal of healthcare engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Retracted:Journal of healthcare engineering · 2023
    Article
4 · The record

Corrections and comments

  • Retraction · 2023-11-01Concerns/Issues about Data · Concerns/Issues about Results and/or Conclusions · Concerns/Issues about Referencing/Attributions · Concerns/Issues about Peer Review · Investigation by Journal/Publisher · Investigation by Third Party · Paper Mill · Computer-Aided Content or Computer-Generated Content · Unreliable Results and/or Conclusions ·
  • Retracted
5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zhitao JiangDepartment of Pharmacy, Zhangjiagang Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Zhangjiagang, Suzhou, Jiangsu 215600, China.
Yi HanDepartment of Pharmacy, Zhangjiagang Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Zhangjiagang, Suzhou, Jiangsu 215600, China.
Yuechan ZhangDepartment of Pharmacy, Zhangjiagang Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Zhangjiagang, Suzhou, Jiangsu 215600, China.
Jie LiDepartment of Pharmacy, Zhangjiagang Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Zhangjiagang, Suzhou, Jiangsu 215600, China.
Chundi LiuDepartment of Pharmacy, Zhangjiagang Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Zhangjiagang, Suzhou, Jiangsu 215600, China.ORCID 0000-0002-0975-4525
Nanjing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Using network pharmacology and in vivo experiments, we investigated the antidrug-induced liver injury components and functional processes of Methods: The effective components, primary active ingredients, and possible target in the therapy of DILI were predicted using network pharmacology and bioinformatics. APAP was inducing the DILI model. In vivo testing of the pharmacodynamic foundation of SSBE in the treatment of DILI was performed. Results: The TCMSP database evaluated five main active components and 299 related targets. In addition, 707 differential genes for DILI were obtained from the DisGeNET database, DigSee database, and OMIM database. 61 related targets were mapped to predict the targets of SSBE acting on DILI. The protein-protein interaction (PPI) core network contained 59 proteins, including IL- Conclusion: By modulating the Nrf2 signaling pathway, the active components in SSBE may protect against drug-induced liver damage.

Indexed as

Chemical and Drug Induced Liver InjuryNF-E2-Related Factor 2SedumAnimalsMiceNetwork PharmacologyPlant ExtractsSignal TransductionNF-E2-Related Factor 2Plant Extracts

Identifiers

PMID34900173
PMCPMC8577938
OpenAlexW3208663310

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.