ReviewJournal of diabetes and metabolic disorders2021
Potential antidiabetic phytochemicals in plant roots: a review of in vivo studies.
Review in Journal of diabetes and metabolic disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 61 citations in OpenAlex.
- Traditional antidiabetic medicinal plants of Himachal Pradesh: ethnomedicinal evidence and drug-discovery potential.Frontiers in nutrition · 2026Review
- SM-GAT: a safety-aware multi-task graph attention network for multi-target anti-diabetic lead discovery from natural products.Frontiers in molecular biosciences · 2026Article
- HPTLC based screening method for the evaluation of α-amylase inhibitory activity in edible flowers.Scientific reports · 2025Article
- Advancing the Potential ofMolecules (Basel, Switzerland) · 2025Review
- A review on the role of functional foods and derivatives for diabetes management.Journal of food science and technology · 2025Review
- Exploration of Antioxidative, Antidiarrheal, and Antihyperglycemic Properties ofBioMed research international · 2025Article
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- Gut microbiota in insulin resistance: a bibliometric analysis.Journal of diabetes and metabolic disorders · 2024Review
- Ethnobotanical assessment of antidiabetic medicinal plants in District Karak, Pakistan.BMC complementary medicine and therapies · 2024Article
- A comprehensiveFrontiers in pharmacology · 2024Review
- Golden thistle (Food science & nutrition · 2023Article
- Ethnobotanical, Phytochemical, Toxicological, and Pharmacological Properties ofPharmaceuticals (Basel, Switzerland) · 2023Review
- Phytochemistry, Biological and Pharmacological Activities of thePlants (Basel, Switzerland) · 2022Review
- Review
- Protective effect of cinnamon on diabetic cardiomyopathy in nicotinamide-streptozotocin induced diabetic rat model.Journal of diabetes and metabolic disorders · 2022Article
- Downregulated hs-CRP and MAD, upregulated GSH and TAC, and improved metabolic status following combined exercise and turmeric supplementation: a clinical trial in middle-aged women with hyperlipidemic type 2 diabetes.Journal of diabetes and metabolic disorders · 2022Article
- Review
- In vitro α-glucosidase inhibitory activity of Tamarix nilotica shoot extracts and fractions.PloS one · 2022Article
- Inhibition mechanism of alpha-amylase, a diabetes target, by a steroidal pregnane and pregnane glycosides derived fromFrontiers in molecular biosciences · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMedicinal plants are used to treat various disorders, including diabetes, globally in a range of formulations. While attention has mainly been on the aerial plant parts, there are only a few review studies to date that are focused on the natural constituents present in the plant roots with health benefits. Thus, the present study was performed to review in vivo studies investigating the antidiabetic potential of the natural compounds in plant roots.
methodsWe sorted relevant data in 2001-2019 from scientific databases and search engines, including Web of Knowledge, PubMed, ScienceDirect, Medline, Reaxys, and Google Scholar. The class of phytochemicals, plant families, major compounds, active constituents, effective dosages, type of extracts, time of experiments, and type of diabetic induction were described.
resultsIn our literature review, we found 104 plants with determined antidiabetic activity in their root extracts. The biosynthesis pathways and mechanism of actions of the most frequent class of compounds were also proposed. The results of this review indicated that flavonoids, phenolic compounds, alkaloids, and phytosteroids are the most abundant natural compounds in plant roots with antidiabetic activity. Phytochemicals in plant roots possess different mechanisms of action to control diabetes, including inhibition of
conclusionThis review concludes that plant roots are a promising source of bioactive compounds which can be explored to develop against diabetes and diabetes-related complications. GRAPHICAL ABSTRACT:
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.