Evidence map›Paper›PMID 34901113›Full record

ArticleFrontiers in nutrition2021

Glucosamine Interferes With Myelopoiesis and Enhances the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells.

Eric Chang-Yi Lin, Shuoh-Wen Chen, Luen-Kui Chen, Ting-An Lin, Yu-Xuan Wu, Chi-Chang Juan, Yuan-I Chang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Comprehensive Research Progress on Glucosamine: A Review.Applied biochemistry and biotechnology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Eric Chang-Yi LinDepartment and Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan.
Shuoh-Wen ChenDepartment and Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan.
Luen-Kui ChenDepartment and Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan.
Ting-An LinDepartment and Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan.
Yu-Xuan WuDepartment and Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan.
Chi-Chang JuanDepartment and Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan.
Yuan-I ChangDepartment and Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan.
National Yang Ming Chiao Tung University · TWTaipei Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucosamine (GlcN) is the most widely consumed dietary supplement and exhibits anti-inflammatory effects. However, the influence of GlcN on immune cell generation and function is largely unclear. In this study, GlcN was delivered into mice to examine its biological function in hematopoiesis. We found that GlcN promoted the production of immature myeloid cells, known as myeloid-derived suppressor cells (MDSCs), both

Indexed as

d-Glucosamine hydrochloride (PubChem CID: 91431)hematopoietic stem cell (HSC)immunosuppressionmyeloid-derived suppressive cellmyelopoiesis

Identifiers

PMID34901113
PMCPMC8660085
OpenAlexW3214662785

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.