Evidence map›Paper›PMID 34901586›Full record

ArticleMaterials today. Chemistry2022

A Review on Antibacterial Silk Fibroin-based Biomaterials: Current State and Prospects.

Sama Ghalei, Hitesh Handa

Abstract read
In one paragraph

Article in Materials today. Chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sama GhaleiSchool of Chemical, Materials and Biomedical Engineering, University of Georgia, Athens 30602, United States.
Hitesh HandaSchool of Chemical, Materials and Biomedical Engineering, University of Georgia, Athens 30602, United States.

Funding

Engineering nitric oxide releasing polymer with immobilized thrombin inhibitor for blood contacting applicationsR01HL134899 · NHLBI · UNIVERSITY OF GEORGIA · PI HANDA, HITESH · 2017 to 2025
$3.0M
NHLBI NIH HHS R01 HL134899
6 · The paper itself

Abstract

Bacterial contamination of biomaterials is a common problem and a serious threat to human health worldwide. Therefore, the development of multifunctional biomaterials that possess antibacterial properties and can resist infection is a continual goal for biomedical applications. Silk fibroin (SF), approved by U.S. Food and Drug Administration (FDA) as a biomaterial, is one of the most widely studied natural polymers for biomedical applications due to its unique mechanical properties, biocompatibility, tunable biodegradation, and versatile material formats. In the last decade, many methods have been employed for the development of antibacterial SF-based biomaterials (SFBs) such as physical loading or chemical functionalization of SFBs with different antibacterial agents and bio-inspired surface modifications. In this review, we first describe the current understanding of the composition and structure-properties relationship of SF as a leading-edge biomaterial. Then we demonstrate the different antibacterial agents and methods implemented for the development of bactericidal SFBs, their mechanisms of action, and different applications. We briefly address their fabrication methods, advantages, and limitations, and finally discuss the emerging technologies and future trends in this research area.

Indexed as

AntibacterialBacteriaBiomaterialsInfectionSilk fibroinSilk fibroin-based biomaterials

Identifiers

PMID34901586
PMCPMC8664245

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.