Evidence map›Paper›PMID 34903141›Full record

ArticleBioengineered2021

Downregulation of Circular RNA PSEN1 ameliorates ferroptosis of the high glucose treated retinal pigment epithelial cells via miR-200b-3p/cofilin-2 axis.

Zhaoliang Zhu, Peng Duan, Huping Song, Rongle Zhou, Tao Chen

Open access · goldAbstract read
In one paragraph

Article in Bioengineered, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
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  6. Article
  7. Review
  8. Article
  9. Emerging role of circular RNAs in diabetic retinopathy.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
    Review
  10. Article
  11. Review
  12. ELAVL1 Stabilizes HMOX1 mRNA to Drive Ferroptosis in Diabetic Retinopathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025
    Article
  13. Review
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zhaoliang ZhuOphthalmology Department, Xi'an People's Hospital, Shaanxi Eye Hospital, Xi'an City, China.
Peng DuanOphthalmology Department, Xi'an People's Hospital, Shaanxi Eye Hospital, Xi'an City, China.
Huping SongOphthalmology Department, Xi'an People's Hospital, Shaanxi Eye Hospital, Xi'an City, China.
Rongle ZhouOphthalmology Department, Xi'an People's Hospital, Shaanxi Eye Hospital, Xi'an City, China.
Tao ChenOphthalmology Department, Xi'an People's Hospital, Shaanxi Eye Hospital, Xi'an City, China.ORCID 0000-0002-6539-6275
Shanxi Eye Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferroptosis is a form of programmed cell death that participates in the progression of numerous diseases. Long noncoding RNAs (lncRNAs) are dysregulated in diabetic retinopathy (DR). However, the role of lncRNAs in DR-induced ferroptosis is unclear. Adult retinal pigment epithelial cell line-19 (ARPE19) cells were treated with a high concentration of glucose (high glucose, HG) to mimic DR

Indexed as

ApoptosisCell LineCell ProliferationCell SurvivalCofilin 2Down-RegulationEpithelial CellsFerroptosisGlucoseHumansMicroRNAsPresenilin-1Retinal PigmentsRNA, Long NoncodingUp-RegulationCofilin 2GlucoseMicroRNAsPresenilin-1PSEN1 protein, humanRetinal PigmentsRNA, Long NoncodingCFL2circ-PSEN1Diabetic retinopathyferroptosismiR-200b-3p

Identifiers

PMID34903141
PMCPMC8809929
OpenAlexW4200253436

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.