ReviewJournal of the Endocrine Society2022
An Approach to the Evaluation and Management of the Obese Child With Early Puberty.
Review in Journal of the Endocrine Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Bibliometric and LDA analysis of the correlation between childhood obesity and precocious puberty (2005-2025).Frontiers in pediatrics · 2026Pooled it
- Obesity, Oxidative Stress, and Inflammation in Precocious Puberty: Do All Roads Lead to the Hypothalamus?International journal of molecular sciences · 2026Review
- Interpreting the GnRH stimulation test in girls with central precocious puberty: the role of age and body mass index.Journal of endocrinological investigation · 2026Article
- Distinguishing central precocious puberty from nonprogressive breast development: adiposity and DXA body composition.Journal of the Endocrine Society · 2026Article
- The diagnostic value and optimal cutoff of basal luteinizing hormone for central precocious puberty in premenarcheal girls stratified by weight status.Frontiers in endocrinology · 2026Article
- The effect of obesity on the GnRH stimulation test in girls with idiopathic central precocious puberty.European journal of pediatrics · 2025Article
- Impact of BMI on basal LH in premenarcheal girls with idiopathic central precocious puberty.Frontiers in endocrinology · 2025Article
- [Value of single-phase gonadotropin-releasing hormone stimulation test in diagnosis of central precocious puberty in girls with different levels of body mass index].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Childhood Obesity, Hypothalamic Inflammation, and the Onset of Puberty: A Narrative Review.Nutrients · 2024Review
- Slower progression of central puberty in overweight girls presenting with precocious breast development.Annals of pediatric endocrinology & metabolism · 2023Article
- [Value of basal luteinizing hormone level combined with uterine volume measurement in the early diagnosis of central precocious puberty in girls with different Tanner stages].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Article
- Links between Childhood Obesity, High-Fat Diet, and Central Precocious Puberty.Children (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the declining age at onset of puberty and increasing prevalence of childhood obesity, early breast development in young obese girls has become a more frequent occurrence. Here, we examine available literature to answer a series of questions regarding how obesity impacts the evaluation and management of precocious puberty. We focus on girls as the literature is more robust, but include boys where literature permits. Suggestions include: (1) Age cutoffs for evaluation of precocious puberty should not differ substantially from those used for nonobese children. Obese girls with confirmed thelarche should be evaluated for gonadotropin-dependent, central precocious puberty (CPP) to determine if further investigation or treatment is warranted. (2) Basal luteinizing hormone (LH) levels remain a recommended first-line test. However, if stimulation testing is utilized, there is a theoretical possibility that the lower peak LH responses seen in obesity could lead to a false negative result. (3) Advanced bone age (BA) is common among obese girls even without early puberty; hence its diagnostic utility is limited. (4) Obesity does not eliminate the need for magnetic resonance imaging in girls with true CPP. Age and clinical features should determine who warrants neuroimaging. (5) BA can be used to predict adult height in obese girls with CPP to inform counseling around treatment. (6) Use of gonadotropin-releasing hormone analogues (GnRHa) leads to increased adult height in obese girls. (7) Obesity should not limit GnRHa use as these agents do not worsen weight status in obese girls with CPP.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.