Evidence map›Paper›PMID 34913271›Full record

ArticleImmunity, inflammation and disease2022

Safety and metabolic advantages of steroid withdrawal after 6 months posttransplant in de novo kidney transplantation: A 1-year prospective cohort study.

Jun B Bang, Chang-Kwon Oh, Yu S Kim, Sung H Kim, Hee C Yu, Chan-Duck Kim, Man Ki Ju, Byung J So, Sang Ho Lee, Sang Y Han and 5 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, inflammation and disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Jun B BangDepartment of Surgery, Ajou University School of Medicine, Suwon, South Korea.ORCID 0000-0003-2271-9596
Chang-Kwon OhDepartment of Surgery, Ajou University School of Medicine, Suwon, South Korea.
Yu S KimDepartment of Transplantation Surgery, Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, South Korea.
Sung H KimDepartment of Surgery, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, South Korea.
Hee C YuDepartment of Surgery, Jeonbuk National University College of Medicine, Jeonju, South Korea.
Chan-Duck KimDepartment of Internal Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.
Man Ki JuDepartment of Surgery, Yonsei University College of Medicine, Seoul, South Korea.
Byung J SoDepartment of Surgery, Wonkwang University Hospital, Iksan, South Korea.
Sang Ho LeeDepartment of Internal Medicine, Kyung Hee University, Seoul, South Korea.
Sang Y HanDepartment of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea.
Cheol W JungDepartment of Surgery, Korea University College of Medicine, Seoul, South Korea.
Joong K KimDepartment of Internal Medicine, Bong Seng Memorial Hospital, Busan, South Korea.
Hyung J AhnDepartment of Surgery, Kyung Hee University School of Medicine, Seoul, South Korea.
Su H LeeDepartment of Surgery, Ajou University School of Medicine, Suwon, South Korea.
Ja Y JeonDepartment of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, South Korea.
Kyung Hee University · KRAjou University · KRYonsei University · KRKorea University · KRJeonju National University of Education · KRKyungpook National University Hospital · KRWonkwang University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis prospective multicenter study aimed at investigating the safety and metabolic advantages of steroid withdrawal (SW) therapy in kidney transplant recipients with tacrolimus-mycophenolate mofetil-based immunosuppression.

methodsWe analyzed 179 recipients who received kidney transplantation from March 2016 and September 2018. In 179 recipients, 114 patients maintained an immunosuppressive regimen including steroids (steroid continuation [SC] group). The remaining 65 patients were determined to withdraw steroid therapy after 6 months posttransplant (SW group). Metabolic parameters and graft functions of the two groups were evaluated.

resultsThe estimated glomerular filtration rates at 12 months posttransplant were 67.29 ± 20.29 ml/min/1.73 m

conclusionIn conclusion, a 6-month withdrawal of steroids in recipients with low immunological risk and stable graft function can be safely conducted and result in improvement of metabolic profiles. Stable recipients without biopsy-proven acute rejection and proteinuria can safely withdraw from steroids out of a maintenance immunosuppressive regimen 6-months posttransplant. A long-term follow-up study is needed to verify our results.

Indexed as

Kidney TransplantationGraft RejectionHumansMycophenolic AcidProspective StudiesSteroidsMycophenolic AcidSteroidscholesterolglucose tolerance testkidney transplantationsteroids

Identifiers

PMID34913271
PMCPMC8926512
OpenAlexW4200069165

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.