Evidence map›Paper›PMID 34917200›Full record

ArticleDisease markers2021

Cox-2 Antagonizes the Protective Effect of Sevoflurane on Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis through Inhibiting the Akt Pathway.

Chunyan Guo, Lei Zhang, Yaoxing Gao, Junzhi Sun, Lingling Fan, Yuguang Bai, Jing Zhang, Gaowa Naren, Jiwen Yang, Libiao Li

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Chunyan GuoDepartment of Anesthesiology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Lei ZhangDepartment of Ultrasound, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Yaoxing GaoDepartment of Anesthesiology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Junzhi SunDepartment of Anesthesiology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Lingling FanDepartment of Anesthesiology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Yuguang BaiDepartment of Anesthesiology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Jing ZhangDepartment of Anesthesiology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Gaowa NarenDepartment of Stomatology, Tongliao Hospital, Tongliao, China.
Jiwen YangDepartment of Neurosurgery, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.ORCID https://orcid.org/0000-0001-8662-6028
Libiao LiDepartment of Anesthesiology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.ORCID https://orcid.org/0000-0001-8572-0215
Inner Mongolia Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo uncover the protective role of sevoflurane on hypoxia/reoxygenation-induced cardiomyocyte apoptosis through the protein kinase B (Akt) pathway.

methodsAn

resultsH/R injury declined viability and enhanced LDH release and apoptotic rate in H9c2 cells. Cyclooxygenase-2 (Cox-2) was upregulated following H/R injury, which was partially reversed by SEV treatment. In addition, SEV treatment reversed changes in viability and LDH release owing to H/R injury in H9c2 cells, which were further aggravated by overexpression of Cox-2. The Akt pathway was inhibited in H9c2 cells overexpressing Cox-2.

conclusionsSevoflurane protects cardiomyocyte damage following H/R

Indexed as

AnimalsApoptosisBiomarkersCardiotonic AgentsCell LineCyclooxygenase 2HypoxiaMyocytes, CardiacProto-Oncogene Proteins c-aktRatsSevofluraneUp-RegulationBiomarkersCardiotonic AgentsCyclooxygenase 2Proto-Oncogene Proteins c-aktPtgs2 protein, ratSevoflurane

Identifiers

PMID34917200
PMCPMC8670977
OpenAlexW4200116681

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.