ArticleBMC chemistry2021
Inonotus obliquus polysaccharide ameliorates serum profiling in STZ-induced diabetic mice model.
Article in BMC chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 15 citations in OpenAlex.
- Selenium-Enriched Submerged Fermentation ofFood science & nutrition · 2025Article
- Antioxidant, Hypoglycemic, and Hypolipidemic Effects of Puerarin In Vivo.Food science & nutrition · 2025Article
- Characterization and Biotechnology of Three New Strains of Basidial Fungi as Promising Sources of Biologically Active Substances.Biotech (Basel (Switzerland)) · 2025Article
- Natural Products and Health Care Functions ofCurrent issues in molecular biology · 2025Review
- Antidiabetic activity ofJournal of complementary & integrative medicine · 2024Article
- Review
- Therapeutic properties ofMycology · 2024Review
- Inulin Reduces Kidney Damage in Type 2 Diabetic Mice by Decreasing Inflammation and Serum Metabolomics.Journal of diabetes research · 2024Article
- Research Progress on Application of Inonotus obliquus in Diabetic Kidney Disease.Journal of inflammation research · 2023Review
- Methanol extract ofFrontiers in endocrinology · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes mellitus is a systemic disease mainly caused by the disorder of metabolism, which has become huge threat to human health. Polysaccharides are the main active substance from Inonotus obliquus (I. obliquus) with hypoglycemic effect. This study aims to evaluate the hypoglycemic activity and investigate the molecular mechanism of I. obliquus polysaccharide (IOP) in streptozotocin (STZ)-induced diabetic mice using metabolomics based on UPLC-Q-Exactive-MS method.
resultsThe results showed that the oral administration of IOP in high dose (1.2 g/kg) can significantly reduce the blood glucose with 31% reduction comparing with the diabetic model and relieve dyslipidemia in diabetic mice. By UPLC-Q-Exactive-MS method and multivariate statistical analysis, a total of 15 differential metabolites were identified, including 4 up-regulated and 11 down-regulated biomarkers, of which L-tryptophan, L-leucine, uric acid, 12-HETE, arachidonic acid, PC(20:1(11Z)/14:1(9Z)) and SM(d18:0/24:1(15Z)) were exhibited an important variation, as the potential biomarkers in diabetes. Pathway analysis indicated that phenylalanine, tyrosine and tryptophan biosynthesis and arachidonic acid metabolism were prone to interference in diabetes. Moreover, leucine and proline were reversed and phytosphingosine was further reduced in diabetic mice under the intervention of IOP.
conclusionIOP has predominant hyperglycemic effect on STZ-induced diabetic mice via ameliorating serum profiling.
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