ReviewTrends in neurosciences2022
Reinforcement learning detuned in addiction: integrative and translational approaches.
Review in Trends in neurosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Neurobehavioral differences in value-based decision making between people with cocaine use disorder and controls.Experimental and clinical psychopharmacology · 2026Article
- Heterogeneous structural brain signatures of methamphetamine and ketamine use disorders revealed by normative modeling.Molecular psychiatry · 2026Article
- Reward Prediction Errors Drive Reinforcement Learning and Recognition Memory: Gender Differences in Methamphetamine Abusers.Brain and behavior · 2026Article
- The mesocorticolimbic system in stimulant use disorder.Molecular psychiatry · 2025Review
- Neural dynamics of reversal learning in the prefrontal cortex and recurrent neural networks.eLife · 2025Article
- Tonic dopamine and biases in value learning linked through a biologically inspired reinforcement learning model.Nature communications · 2025Article
- Shared orbitofrontal dynamics to a drug-themed movie track craving and recovery in heroin addiction.Brain : a journal of neurology · 2025Article
- Disruptions in Reward-Guided Decision-Making Functions Are Predictive of Greater Oral Oxycodone Self-Administration in Male and Female Rats.Biological psychiatry global open science · 2025Article
- Chronic ethanol exposure produces sex-dependent impairments in value computations in the striatum.Science advances · 2025Article
- Chronic Ethanol Exposure Produces Persistent Impairment in Cognitive Flexibility and Decision Signals in the Striatum.bioRxiv : the preprint server for biology · 2025Article
- Impact of provoked stress on model-free and model-based reinforcement learning in individuals with alcohol use disorder.Addictive behaviors reports · 2024Article
- Functional specialization of medial and lateral orbitofrontal cortex in inferential decision-making.iScience · 2024Article
- Naturalistic drug cue reactivity in heroin use disorder: orbitofrontal synchronization as a marker of craving and recovery.medRxiv : the preprint server for health sciences · 2024Article
- Neural correlates of model-based behavior in internet gaming disorder and alcohol use disorder.Journal of behavioral addictions · 2024Article
- The Neural Correlates of Individual Differences in Reinforcement Learning during Pain Avoidance and Reward Seeking.eNeuro · 2024Article
- Exploring the steps of learning: computational modeling of initiatory-actions among individuals with attention-deficit/hyperactivity disorder.Translational psychiatry · 2024Article
- Medial prefrontal cortex suppresses reward-seeking behavior with risk of punishment by reducing sensitivity to reward.Frontiers in neuroscience · 2024Article
- Article
- The Development of Speaking and Singing in Infants May Play a Role in Genomics and Dementia in Humans.Brain sciences · 2023Review
- A morphine reward generalization mouse model based on conditioned place preference and aversion.Brain and behavior · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Suboptimal decision-making strategies have been proposed to contribute to the pathophysiology of addiction. Decision-making, however, arises from a collection of computational components that can independently influence behavior. Disruptions in these different components can lead to decision-making deficits that appear similar behaviorally, but differ at the computational, and likely the neurobiological, level. Here, we discuss recent studies that have used computational approaches to investigate the decision-making processes underlying addiction. Studies in animal models have found that value updating following positive, but not negative, outcomes is predictive of drug use, whereas value updating following negative, but not positive, outcomes is disrupted following drug self-administration. We contextualize these findings with studies on the circuit and biological mechanisms of decision-making to develop a framework for revealing the biobehavioral mechanisms of addiction.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.