ArticleProceedings of the National Academy of Sciences of the United States of America2021
Microbiome-mediated incapacitation of interferon lambda production in the oral mucosa.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Gingipain proteases from the bacteriumProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Porphyromonas gingivalis Suppresses Interferon-Gamma Signaling in Macrophages Through a Contact-Dependent, Gingipain-Mediated Mechanism.MicrobiologyOpen · 2026Article
- Ultrasmall oral Saccharibacteria modulate gingival immunoactivation through type IV pili and TLR2-dependent endocytosis.Nature communications · 2026Article
- The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease.Journal of internal medicine · 2026Review
- Colonization by Porphyromonas gingivalis in cervical squamous cell carcinomas promotes metastasis through FimA/CD151/ITGB1 signaling.Journal of translational medicine · 2025Article
- Lys-specific gingipain (Kgp) ofmBio · 2025Article
- Article
- One-carbon metabolism and microbial pathogenicity.Molecular oral microbiology · 2024Review
- Article
- Interferon-λ Activates a Differential Response in Peripheral Neurons That Is Effective against Alpha Herpesvirus Infections.Pathogens (Basel, Switzerland) · 2023Article
- Roles and Effects of Interferon Lambda Signaling in the Context of Bacterial Infections.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2023Review
- Review
- Illuminating the oral microbiome: cellular microbiology.FEMS microbiology reviews · 2023Article
- P. gingivalis Infection Upregulates PD-L1 Expression on Dendritic Cells, Suppresses CD8+ T-cell Responses, and Aggravates Oral Cancer.Cancer immunology research · 2023Article
- Gut-brain pathogenesis of post-acute COVID-19 neurocognitive symptoms.Frontiers in neuroscience · 2023Article
- Molecular basis of cycloheximide resistance in the Ophiostomatales revealed.Current genetics · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 2 institutions in 1 country.
Carlos J Rodriguez-HernandezDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY 40202.ORCID 0000-0002-9000-6427
Kevin J SokoloskiDepartment of Microbiology and Immunology, University of Louisville, Louisville, KY 40202.ORCID 0000-0002-8728-2340
Kendall S StockeDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY 40202.
Himabindu DukkaDepartment of Diagnosis and Oral Health, University of Louisville, Louisville, KY 40202.
Shunying JinDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY 40202.
Melissa A MetzlerDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY 40202.
Konstantin ZaitsevDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.
Boris ShpakDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.
Daonan ShenDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY 40202.
Daniel P MillerDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY 40202.ORCID 0000-0002-1332-5870
Maxim N ArtyomovDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.
Richard J LamontDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY 40202; juhi.bagaitkar@louisville.edu rich.lamont@louisville.edu.ORCID 0000-0002-3147-5039
Juhi BagaitkarDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY 40202; juhi.bagaitkar@louisville.edu rich.lamont@louisville.edu.ORCID 0000-0001-6185-1915
University of Louisville · USWashington University in St. Louis · US
Funding
WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ERIC C ROUCHKA · 2012 to 2026
$60.1MUnderstanding the Host-Microbiome-Therapeutic Triad: Implications for Designing Alternative IntravaginalP20GM125504 · NIGMS · UNIVERSITY OF LOUISVILLE · PI James Tristan Collins · 2018 to 2026
$24.4MMOLECULAR ASPECTS OF ORAL PLAQUE FORMATIONR01DE012505 · NIDCR · UNIVERSITY OF WASHINGTON · PI Richard J Lamont, JAN S POTEMPA · 1998 to 2026
$9.5MP GINGIVALIS INTERACTIONS WITH GINGIVAL EPITHELIAL CELLSR01DE011111 · NIDCR · UNIVERSITY OF WASHINGTON · PI HARIBABU BODDULURI, Richard J Lamont · 1995 to 2026
$5.4MProbing Polymicrobial Synergy Using hihg Throughout GenomicsR01DE023193 · NIDCR · UNIVERSITY OF TEXAS AT AUSTIN · PI LAMONT, RICHARD J, WHITELEY, MARVIN · 2013 to 2023
$4.7MP.gingivalis Interactions with Gingival Epithelial CellsR37DE011111 · NIDCR · UNIVERSITY OF LOUISVILLE · PI LAMONT, RICHARD J · 2009 to 2018
$3.6MRole of JAKs in innate responses to P. gingivalisR01DE017921 · NIDCR · UNIVERSITY OF LOUISVILLE · PI LAMONT, RICHARD J · 2010 to 2019
$3.3MRedox Regulation of Gingival InflammationR01DE028296 · NIDCR · UNIVERSITY OF LOUISVILLE · PI BAGAITKAR, JUHI · 2020 to 2024
$2.3MInflammation and Pathogenesis Training ProgramT32AI132146 · NIAID · UNIVERSITY OF LOUISVILLE · PI LAMONT, RICHARD J, MITCHELL, THOMAS C. · 2018 to 2022
$640kA novel role for NADPH oxidase in modulating neutrophil functions in periodontal diseaseR03DE028031 · NIDCR · UNIVERSITY OF LOUISVILLE · PI BAGAITKAR, JUHI · 2018 to 2019
$308kNIAID NIH HHS T32 AI132146NIDCR NIH HHS R01 DE011111NIDCR NIH HHS R01 DE012505NIDCR NIH HHS R01 DE017921NIDCR NIH HHS R01 DE023193NIDCR NIH HHS R01 DE028296NIDCR NIH HHS R03 DE028031NIDCR NIH HHS R37 DE011111NIGMS NIH HHS P20 GM103436NIGMS NIH HHS P20 GM125504
Abstract
Here, we show that
Indexed as
MicrobiotaAnimalsCell LineGingivaHost-Pathogen InteractionsHumansInterferon LambdaInterferonsInterleukinsMicePorphyromonas gingivalisPrimary Cell CultureInterferon Lambdainterferon-lambda, humanInterferonsInterleukinsInterferon lambdaoral epithelial cellsperiodontitisPorphyromonas gingivalisviral infection
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.