Evidence map›Paper›PMID 34923568›Full record

ArticleCell death & disease2021

Sidt2 is a key protein in the autophagy-lysosomal degradation pathway and is essential for the maintenance of kidney structure and filtration function.

Meng-Ya Geng, Lizhuo Wang, Ying-Ying Song, Jing Gu, Xin Hu, Cheng Yuan, Meng Yang, Wen-Jun Pei, Yao Zhang, Jia-Lin Gao

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 35 citations in OpenAlex.

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  14. [Lysosomal membrane proteinNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Meng-Ya Geng *Department of Endocrinology and Genetic Metabolism, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, 241001, People's Republic of China.
Lizhuo Wang *Anhui Province Key Laboratory of Biological Macro-molecules Research (Wannan Medical College), Wannan Medical College, Wuhu, 241002, People's Republic of China.
Ying-Ying SongDepartment of Endocrinology and Genetic Metabolism, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, 241001, People's Republic of China.
Jing GuDepartment of Endocrinology and Genetic Metabolism, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, 241001, People's Republic of China.
Xin HuDepartment of Endocrinology and Genetic Metabolism, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, 241001, People's Republic of China.
Cheng YuanSchool of Clinical Medicine, Wannan Medical College, Wuhu, 241002, People's Republic of China.
Meng YangSchool of Clinical Medicine, Wannan Medical College, Wuhu, 241002, People's Republic of China.
Wen-Jun PeiAnhui Province Key Laboratory of Biological Macro-molecules Research (Wannan Medical College), Wannan Medical College, Wuhu, 241002, People's Republic of China.
Yao ZhangAnhui Province Key Laboratory of Biological Macro-molecules Research (Wannan Medical College), Wannan Medical College, Wuhu, 241002, People's Republic of China.
Jia-Lin GaoDepartment of Endocrinology and Genetic Metabolism, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, 241001, People's Republic of China. gaojialin@wnmc.edu.cn.ORCID http://orcid.org/0000-0001-7669-2785
Wannan Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The regulation and homeostasis of autophagy are essential for maintaining organ morphology and function. As a lysosomal membrane protein, the effect of Sidt2 on kidney structure and renal autophagy is still unknown. In this study, we found that the kidneys of Sidt2

Indexed as

AnimalsAutophagyDisease Models, AnimalHumansLysosomesMaleMiceNucleotide Transport ProteinsTransfectionNucleotide Transport ProteinsSidt2 protein, mouse

Identifiers

PMID34923568
PMCPMC8684554
OpenAlexW4200247012

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.