Evidence map›Paper›PMID 34924936›Full record

ArticleFrontiers in neuroscience2021

Sex and Genotype Modulate the Dendritic Effects of Developmental Exposure to a Human-Relevant Polychlorinated Biphenyls Mixture in the Juvenile Mouse.

Kimberly P Keil Stietz, Sunjay Sethi, Carolyn R Klocke, Tryssa E de Ruyter, Machelle D Wilson, Isaac N Pessah, Pamela J Lein

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 19 citations in OpenAlex.

  1. Expression of the Human R163C-International journal of molecular sciences · 2026
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  14. Gene×environment interactions in autism spectrum disorders.Current topics in developmental biology · 2023
    Review
  15. Article
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  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kimberly P Keil StietzDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
Sunjay SethiDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
Carolyn R KlockeDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
Tryssa E de RuyterDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
Machelle D WilsonClinical and Translational Science Center, Division of Biostatistics, Department of Public Health Sciences, School of Medicine, University of California, Davis, Davis, CA, United States.
Isaac N PessahDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
Pamela J LeinDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
University of California, Davis · US

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI KC KENT LLOYD · 2002 to 2026
$84.9M
Training CoreP42ES013661 · NIEHS · UNIVERSITY OF IOWA · PI HANS-JOACHIM LEHMLER · 2006 to 2026
$60.3M
UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
UC Davis Environmental Health Sciences Core CenterP30ES023513 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Irva Hertz-Picciotto · 2015 to 2026
$26.0M
Research Project: Pathologic Significance of Maternal AutoantibodiesP50HD103526 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEONARD J. ABBEDUTO, Melissa Dawn Bauman · 2020 to 2026
$9.7M
Molecular and Cellular Basis of PCB Developmental Neurotoxicity: ViCTER supplementR01ES014901 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HANS-JOACHIM LEHMLER, Pamela J Lein · 2009 to 2026
$9.3M
ENVIRONMENTAL TOXICOLOGYT32ES007059 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura S Van Winkle · 1985 to 2026
$7.9M
PCB Epigenomic Brain & Behavior Lasting Effects Study (PEBBLES)R01ES029213 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Janine M LaSalle, Pamela J Lein · 2018 to 2026
$6.5M
PCB induced neurogenic inflammation mediates bladder dysfunctionR00ES029537 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI STIETZ, KIMBERLY PRESTON KEIL · 2020 to 2023
$747k
PCBs and heritable mutations in calcium signaling act via DNA methylation to disrupt dendritic growth andplasticityF32HD088016 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI STIETZ, KIMBERLY PRESTON KEIL · 2016 to 2018
$135k
NCATS NIH HHS UL1 TR001860NCI NIH HHS P30 CA093373NICHD NIH HHS F32 HD088016NICHD NIH HHS P50 HD103526NIEHS NIH HHS P30 ES023513NIEHS NIH HHS P42 ES013661NIEHS NIH HHS R00 ES029537NIEHS NIH HHS R01 ES014901NIEHS NIH HHS R01 ES029213NIEHS NIH HHS T32 ES007059
6 · The paper itself

Abstract

While many neurodevelopmental disorders (NDDs) are thought to result from interactions between environmental and genetic risk factors, the identification of specific gene-environment interactions that influence NDD risk remains a critical data gap. We tested the hypothesis that polychlorinated biphenyls (PCBs) interact with human mutations that alter the fidelity of neuronal Ca

Indexed as

FMR1 premutationgene–environment interactionGolgi stainneurodevelopmental disordersryanodine receptorSholl analysis

Identifiers

PMID34924936
PMCPMC8678536
OpenAlexW4200328602

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.