Evidence map›Paper›PMID 34928757›Full record

ArticleThe Journal of asthma : official journal of the Association for the Care of Asthma2022

Interleukin (IL)-33 immunobiology in asthma and airway inflammatory diseases.

Rohit Gaurav, Jill A Poole

Open access · greenAbstract read
In one paragraph

Article in The Journal of asthma : official journal of the Association for the Care of Asthma, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Ameliorating Effects ofAntioxidants (Basel, Switzerland) · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Serum 17Frontiers in immunology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. An ALARMINg Type 2 Response in Cystic Fibrosis-The Key to Understanding ABPA?American journal of respiratory and critical care medicine · 2023
    Article
  12. The IL-33/IL-31 Axis in Allergic and Immune-Mediated Diseases.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rohit GauravDepartment of Internal Medicine, Division of Allergy and Immunology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0003-4753-2680
Jill A PooleDepartment of Internal Medicine, Division of Allergy and Immunology, University of Nebraska Medical Center, Omaha, NE, USA.
University of Nebraska Medical Center · US

Funding

Surveillance of Agricultural Injuries in the Central States RegionsU54OH010162 · OH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI RAUTIAINEN, RISTO HEIKKI · 2011 to 2025
$23.6M
Role of pattern recognition receptors in organic dust-induced airway inflammationR01ES019325 · NIEHS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI POOLE, JILL A · 2010 to 2020
$3.7M
Resolving Occupational Exposure-Induced Lung DiseaseR01OH012045 · OH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI POOLE, JILL A · 2021 to 2024
$2.3M
NIEHS NIH HHS R01 ES019325NIOSH CDC HHS R01 OH012045NIOSH CDC HHS U54 OH010162
6 · The paper itself

Abstract

objectiveIdentify key features of IL-33 immunobiology important in allergic and nonallergic airway inflammatory diseases and potential therapeutic strategies to reduce disease burden. DATA SOURCES: PubMed, clinicaltrials.gov. STUDY SELECTIONS: A systematic and focused literature search was conducted of PubMed from March 2021 to December 2021 using keywords to either PubMed or BioMed Explorer including IL-33/ST2, genetic polymorphisms, transcription, translation, post-translation modification, nuclear protein, allergy, asthma, and lung disease. Clinical trial information on IL-33 was extracted from clinicaltrials.gov in August 2021.

resultsIn total, 72 publications with relevance to IL-33 immunobiology and/or clinical lung disease were identified (allergic airway inflammation/allergic asthma

conclusionAn integral role of IL-33 in the pathogenesis of allergic and nonallergic airway inflammatory disease is evident with several emerging clinical trials investigating therapeutic approaches. Current data support a critical role of IL-33 in damage signaling, repair and regeneration of lungs.

Indexed as

AsthmaCOVID-19HypersensitivityHumansInflammationInterleukin-1 Receptor-Like 1 ProteinInterleukin-33LungInterleukin-1 Receptor-Like 1 ProteinInterleukin-33allergic asthmaasthma-COPD overlapCOVID-19IL-33lung fibrosisnon-allergic asthmaregenerationrepair

Identifiers

PMID34928757
PMCPMC9234100
OpenAlexW4200315209

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.