Evidence map›Paper›PMID 34930449›Full record

ArticleClinical epigenetics2021

Reproductive history and blood cell DNA methylation later in life: the Young Finns Study.

Emily W Harville, Pashupati P Mishra, Mika Kähönen, Emma Raitoharju, Saara Marttila, Olli Raitakari, Terho Lehtimäki

Abstract read
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In one paragraph

Article in Clinical epigenetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Pregnancy is linked to faster epigenetic aging in young women.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Associations between epigenetic age acceleration and infertility.Human reproduction (Oxford, England) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emily W HarvilleDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, 70112, USA. harville@tulane.edu.ORCID 0000-0003-0319-0922
Pashupati P MishraDepartment of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, 33520, Tampere, Finland.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33521, Tampere, Finland.
Emma RaitoharjuDepartment of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, 33520, Tampere, Finland.
Saara MarttilaDepartment of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, 33520, Tampere, Finland.
Olli RaitakariResearch Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Terho LehtimäkiDepartment of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, 33520, Tampere, Finland.

Funding

National Academy of Finland 117787 (Gendi)National Academy of Finland 121584National Academy of Finland 124282National Academy of Finland 126925National Academy of Finland 129378 (Salve)National Academy of Finland 134309 (Eye)National Academy of Finland 285902National Academy of Finland 286284National Academy of Finland 322098National Academy of Finland 330809National Academy of Finland 338395National Academy of Finland 41071 (Skidi)
6 · The paper itself

Abstract

backgroundWomen with a history of complications of pregnancy, including hypertensive disorders, gestational diabetes or an infant fetal growth restriction or preterm birth, are at higher risk for cardiovascular disease later in life. We aimed to examine differences in maternal DNA methylation following pregnancy complications.

methodsData on women participating in the Young Finns study (n = 836) were linked to the national birth registry. DNA methylation in whole blood was assessed using the Infinium Methylation EPIC BeadChip. Epigenome-wide analysis was conducted on differential CpG methylation at 850 K sites. Reproductive history was also modeled as a predictor of four epigenetic age indices.

resultsFourteen significant differentially methylated sites were found associated with both history of pre-eclampsia and overall hypertensive disorders of pregnancy. No associations were found between reproductive history and any epigenetic age acceleration measure.

conclusionsDifferences in epigenetic methylation profiles could represent pre-existing risk factors, or changes that occurred as a result of experiencing these complications.

Indexed as

Blood CellsReproductive HistoryAdultArea Under CurveDNA MethylationFemaleFinlandGenome-Wide Association StudyHumansInfant, NewbornMaleProportional Hazards ModelsROC CurveSurvival AnalysisDNA methylationEpigeneticsPre-eclampsiaPregnancyReproductive history

Identifiers

PMID34930449
PMCPMC8690999

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.