Evidence mapPaperPMID 34932890Full record

ReviewObesity (Silver Spring, Md.)2022

Body composition and cardiometabolic health across the menopause transition.

Kara L Marlatt, Dori R Pitynski-Miller, Kathleen M Gavin, Kerrie L Moreau, Edward L Melanson, Nanette Santoro, Wendy M Kohrt

Abstract readReview
In one paragraph

Review in Obesity (Silver Spring, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 4 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Effects of physical exercise on the lipid profile of perimenopausal and postmenopausal women: a systematic review and meta-analysis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
    Pooled it
  5. Trial
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  8. Article
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  10. The HIV Reservoir and Immune Landscape Across the Life Course of Women: Implications for Cure Strategies.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
  11. Article
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  18. Loss of ovarian function and estrogen therapy remodel the brain's synaptic and metabolic proteome.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Article
  19. Review
  20. Article

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kara L MarlattPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID 0000-0001-7721-7900
Dori R Pitynski-MillerDivision of Geriatric Medicine, Department of MedicineUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0002-1527-1263
Kathleen M GavinDivision of Geriatric Medicine, Department of MedicineUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0003-4102-8424
Kerrie L MoreauDivision of Geriatric Medicine, Department of MedicineUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0001-9298-047X
Edward L MelansonDivision of Geriatric Medicine, Department of MedicineUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0001-9151-9745
Nanette SantoroDepartment of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0001-9096-7490
Wendy M KohrtDivision of Geriatric Medicine, Department of MedicineUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · UNIVERSITY OF COLORADO DENVER · 1995 to 2025
$7.7M
Molecular Transducers of Physical Activity Consortium - Colorado Clinical CenterU01AR071124 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 2022 to 2022
$6.5M
Louisiana Clinical and Translational Science CenterU54GM104940 · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2025 to 2025
$3.9M
Pilot and Feasibility ProgramP30DK072476 · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2005 to 2025
$2.2M
UCHSC AGING TRAINING GRANTT32AG000279 · UNIVERSITY OF COLORADO DENVER · 2001 to 2025
$2.0M
The Colorado Building Interdisciplinary Research Careers in Women's Health ProgramK12AR084226 · UNIVERSITY OF COLORADO DENVER · 2025 to 2025
$648k
Mechanism and Modulation of Sex Differences in Myocardial Steatosis Induced Left Ventricular DysfunctionR01HL136601 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI Michael Douglas Nelson · 2022 to 2022
$590k
The Clinical Research/Reproductive Scientist Training Program (CREST)R25HD075737 · NICHD · UNIVERSITY OF COLORADO DENVER · 2023 to 2025
$310k
NCATS NIH HHS UL1 TR002535NHLBI NIH HHS R01 HL136601NHLBI NIH HHS R01 HL146558NIAMS NIH HHS K12 AR084226NIAMS NIH HHS U01 AR071124NIA NIH HHS R01 AG049762NIA NIH HHS R13 AG069384NIA NIH HHS T32 AG000279NIA NIH HHS U54 AG062319NICHD NIH HHS R01 HD087314NICHD NIH HHS R01 HD100343NICHD NIH HHS R25 HD075737NIDDK NIH HHS K01 DK109053NIDDK NIH HHS K01 DK128227NIDDK NIH HHS P30 DK048520NIDDK NIH HHS P30 DK072476NIDDK NIH HHS R01 DK112260NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

Every year, 2 million women reach menopause in the United States, and they may spend 40% or more of their life in a postmenopausal state. In the years immediately preceding menopause-known as the menopause transition (or perimenopause)-changes in hormones and body composition increase a woman's overall cardiometabolic risk. In this narrative review, we summarize the changes in weight, body composition, and body fat distribution, as well as the changes in energy intake, energy expenditure, and other cardiometabolic risk factors (lipid profile, glucose metabolism, sleep health, and vascular function), that occur during the menopause transition. We also discuss the benefits of lifestyle interventions in women in the earlier stages of menopause before these detrimental changes occur. Finally, we discuss how to include perimenopausal women in research studies so that women across the life-span are adequately represented.

Indexed as

Cardiovascular DiseasesMenopauseBody CompositionEnergy MetabolismFemaleHumansPerimenopause

Identifiers

PMID34932890
PMCPMC8972960

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.