Evidence map›Paper›PMID 34934475›Full record

ReviewThe World Allergy Organization journal2021

WAO-ARIA consensus on chronic cough - Part 1: Role of TRP channels in neurogenic inflammation of cough neuronal pathways.

Philip W Rouadi, Samar A Idriss, Jean Bousquet, Tanya M Laidlaw, Cecilio R Azar, Mona Sulaiman Al-Ahmad, Anahí Yáñez, Maryam Ali Y Al-Nesf, Talal M Nsouli, Sami L Bahna and 30 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The World Allergy Organization journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. WAO - ARIA consensus on chronic cough: Executive summary.The World Allergy Organization journal · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Phenotypes and endotypes of cough in asthma.Therapeutic advances in respiratory disease
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors at 20 institutions in 24 countries.

Philip W RouadiDepartment of Otolaryngology - Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon.
Samar A IdrissDepartment of Otolaryngology - Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon.
Jean BousquetHospital Charité, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Tanya M LaidlawDepartment of Medicine, Harvard Medical School, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital Boston, MA, USA.
Cecilio R AzarDepartment of Gastroenterology, American University of Beirut Medical Center (AUBMC), Beirut, Lebanon.
Mona Sulaiman Al-AhmadDepartment of Microbiology, Faculty of Medicine, Kuwait University, Kuwait.
Anahí YáñezINAER - Investigaciones en Alergia y Enfermedades Respiratorias, Buenos Aires, Argentina.
Maryam Ali Y Al-NesfAllergy and Immunology Section, Department of Medicine, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar.
Talal M NsouliInternational Cough Institute, Washington D.C, USA.
Sami L BahnaAllergy & Immunology Section, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Eliane Abou-JaoudeInternational Cough Institute, Washington D.C, USA.
Fares H ZaitounDepartment of Allergy Otolaryngology, LAU-RIZK Medical Center, Beirut, Lebanon.
Usamah M HadiClinical Professor Department of Otolaryngology Head and Neck Surgery, American University of Beirut, Lebanon.
Peter W HellingsKU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Allergy and Clinical Immunology, Leuven, Belgium.
Glenis K ScaddingDepartment of ENT, RNENT Hospital, London, UK.
Peter K SmithClinical Medicine Griffith University, Southport Qld, 4215, Australia.
Mario Morais-AlmeidaAllergy Center, CUF Descobertas Hospital, Lisboa, Portugal.
R Maximiliano GómezSchool of Health Sciences, Catholic University of Salta, Argentina.
Sandra N González DíazUniversidad Autónoma de Nuevo León, Hospital Universitario and Facultad de Medicina, Monterrey, Nuevo León, Mexico.
Ludger KlimekCenter for Rhinology and Allergology, Wiesbaden, Germany.
Georges S JuvelekianDepartment of Pulmonary, Critical Care and Sleep Medicine at Saint George Hospital University Medical Center, Beirut, Lebanon.
Moussa A RiachyDepartment of Pulmonary and Critical Care, Hôtel-Dieu de France University Hospital, Beirut, Lebanon.
Giorgio Walter CanonicaHumanitas University, Personalized Medicine Asthma & Allergy Clinic-Humanitas Research Hospital-IRCCS-Milano Italy.
David PedenUNC Center for Environmental Medicine, Asthma, and Lung Biology, Division of Allergy, Immunology and Rheumatology, Department of Pediatrics UNS School of Medicine, USA.
Gary W K WongDepartment of Pediatrics, Chinese University of Hong Kong, Hong Kong, China.
James SublettDepartment of Pediatrics, Section of Allergy and Immunology, University of Louisville School of Medicine, 9800 Shelbyville Rd, Louisville, KY, USA.
Jonathan A BernsteinUniversity of Cincinnati College of Medicine, Department of Internal Medicine, Division of Immunology/Allergy Section, Cincinnati.
Lianglu WangDepartment of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Disease, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing 100730, China.
Luciana Kase TannoUniversité Montpellier, Montpellier, France.
Manana ChikhladzeMedical Faculty at Akaki Tsereteli State University, National Institute of Allergy, Asthma & Clinical Immunology, KuTaisi, Tskaltubo, Georgia.
Michael LevinDivision of Paediatric Allergology, Department of Paediatrics, University of Cape Town, South Africa.
Yoon-Seok ChangDivision of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea.
Bryan L MartinDepartment of Otolaryngology, Division of Allergy & Immunology, The Ohio State University, Columbus, OH, USA.
Luis CaraballoInstitute for Immunological Research, University of Cartagena. Cartagena de Indias, Colombia.
Adnan CustovicNational Heart and Lund Institute, Imperial College London, UK.
José Antonio Ortega-MartellHealth Science Institute, Autonomous University of Hidalgo, Mexico.
Erika Jensen-JarolimInstitute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University Vienna, Austria.
Motohiro EbisawaClinical Research Center for Allergy and Rheumatology,National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan.
Alessandro FiocchiTranslational Pediatric Research Area, Allergic Diseases Research Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Holy See.
Ignacio J AnsoteguiDepartment of Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain.
Hôtel-Dieu de France · LBAdministración Nacional de Laboratorios e Institutos de Salud · ARAkaki Tsereteli State University · GEAmerican University of Beirut · LBBambino Gesù Children's Hospital · ITBrigham and Women's Hospital · USChinese University of Hong Kong · HKGriffith University · AUHamad Medical Corporation · QAHospital do Desterro · PTHospital Quirónsalud Barcelona · ESHumboldt-Universität zu Berlin · DEImperial College London · GBIRCCS Humanitas Research Hospital · ITKuwait University · KWLouisiana State University Health Sciences Center Shreveport · USMedical University of Vienna · ATMiddle East University · LBNational Sagamihara Hospital · JPPeking Union Medical College Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCough features a complex peripheral and central neuronal network. The function of the chemosensitive and stretch (afferent) cough receptors is well described but partly understood. It is speculated that chronic cough reflects a neurogenic inflammation of the cough reflex, which becomes hypersensitive. This is mediated by neuromediators, cytokines, inflammatory cells, and a differential expression of neuronal (chemo/stretch) receptors, such as transient receptor potential (TRP) and purinergic P2X ion channels; yet the overall interaction of these mediators in neurogenic inflammation of cough pathways remains unclear.

objectivesThe World Allergy Organization/Allergic Rhinitis and its Impact on Asthma (WAO/ARIA) Joint Committee on Chronic Cough reviewed the current literature on neuroanatomy and pathophysiology of chronic cough. The role of TRP ion channels in pathogenic mechanisms of the hypersensitive cough reflex was also examined. OUTCOMES: Chemoreceptors are better studied in cough neuronal pathways compared to stretch receptors, likely due to their anatomical overabundance in the respiratory tract, but also their distinctive functional properties. Central pathways are important in suppressive mechanisms and behavioral/affective aspects of chronic cough. Current evidence strongly suggests neurogenic inflammation induces a hypersensitive cough reflex marked by increased expression of neuromediators, mast cells, and eosinophils, among others. TRP ion channels, mainly TRP V1/A1, are important in the pathogenesis of chronic cough due to their role in mediating chemosensitivity to various endogenous and exogenous triggers, as well as a crosstalk between neurogenic and inflammatory pathways in cough-associated airways diseases.

Indexed as

ChemoreceptorsChronic coughMechanoreceptorsP2X3PathogenesisTRP channel

Identifiers

PMID34934475
PMCPMC8654622
OpenAlexW4200393790

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.