Evidence map›Paper›PMID 34934939›Full record

ArticleMatrix biology plus2021

Biophotonic tools for probing extracellular matrix mechanics.

B E Sherlock, J Chen, J C Mansfield, E Green, C P Winlove

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Matrix biology plus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

B E SherlockCollege of Medicine and Health, University of Exeter, Exeter EX1 2LU, United Kingdom.
J ChenCollege of Engineering, Mathematical and Physical Sciences, University of Exeter, Exeter EX4 4QF, United Kingdom.
J C MansfieldCollege of Engineering, Mathematical and Physical Sciences, University of Exeter, Exeter EX4 4QF, United Kingdom.
E GreenCollege of Engineering, Mathematical and Physical Sciences, University of Exeter, Exeter EX4 4QF, United Kingdom.
C P WinloveCollege of Engineering, Mathematical and Physical Sciences, University of Exeter, Exeter EX4 4QF, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The complex, hierarchical and heterogeneous biomechanics of the extracellular matrix (ECM) are central to the health of multicellular organisms. Characterising the distribution, dynamics and above all else origins of ECM biomechanics are challenges that have captivated researchers for decades. Recently, a suite of biophotonics techniques have emerged as powerful new tools to investigate ECM biomechanics. In this mini-review, we discuss how the non-destructive, sub-micron resolution imaging capabilities of Raman spectroscopy and nonlinear microscopy are being used to interrogate the biomechanics of thick, living tissues. These high speed, label-free techniques are implemented during mechanical testing, providing unprecedented insight into the compositional and structural response of the ECM to changes in the mechanical environment.

Indexed as

BiomechanicsBiophotonicsCollagenExtracellular matrix mechanics, tissue engineeringLongitudinal monitoringNonlinear microscopyRaman spectroscopySecond harmonic generation

Identifiers

PMID34934939
PMCPMC8661043

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.