ArticleCurrent topics in behavioral neurosciences2022
A Computational View on the Nature of Reward and Value in Anhedonia.
Article in Current topics in behavioral neurosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The behavioural effects of the serotonin 1A receptor agonist buspirone on reward processing in healthy volunteers: A randomised, placebo-controlled study.Journal of psychopharmacology (Oxford, England) · 2026Trial
- Computationally Informed Insights Into Anhedonia and Treatment by Kappa Opioid Receptor Antagonism.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Trial
- Blunted anticipation, but not consummation, of food rewards in depression.Cell reports. Medicine · 2026Article
- From Neural Circuits to Behavior: Examining the Central Role of Anhedonia in Major Depression.Advances in experimental medicine and biology · 2026Review
- Higher motivation and pleasure scores predict more reliance on model-free decision making.Cognitive, affective & behavioral neuroscience · 2025Article
- Cognitive Control in Schizophrenia: Advances in Computational Approaches.Current directions in psychological science · 2024Article
- Depression is associated with reduced outcome sensitivity in a dual valence, magnitude learning task.Psychological medicine · 2024Article
- Having multiple selves helps learning agents explore and adapt in complex changing worlds.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Fifty years on: Serotonin and depression.Journal of psychopharmacology (Oxford, England) · 2023Review
- Emotions as computations.Neuroscience and biobehavioral reviews · 2023Review
- Mindfulness-Based Stress Reduction Specifically Improves Social Anhedonia Among Adults with Chronic Stress.Affective science · 2022Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anhedonia - a common feature of depression and other neuropsychiatric disorders - encompasses a reduction in the subjective experience and anticipation of rewarding events, and a reduction in the motivation to seek out such events. The presence of anhedonia often predicts or accompanies treatment resistance, and as such better interventions and treatments are important. Yet the mechanisms giving rise to anhedonia are not well understood. In this chapter, we briefly review existing computational conceptualisations of anhedonia. We argue that they are mostly descriptive and fail to provide an explanatory account of why anhedonia may occur. Working within the framework of reinforcement learning, we examine two potential computational mechanisms that could give rise to anhedonic phenomena. First, we show how anhedonia can arise in multi-dimensional drive-reduction settings through a trade-off between different rewards or needs. We then generalise this in terms of model-based value inference and identify a key role for associational belief structure. We close with a brief discussion of treatment implications of both of these conceptualisations. In summary, computational accounts of anhedonia have provided a useful descriptive framework. Recent advances in reinforcement learning suggest promising avenues by which the mechanisms underlying anhedonia may be teased apart, potentially motivating novel approaches to treatment.
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34935117What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.