Evidence map›Paper›PMID 34935944›Full record

ArticleThe Journal of clinical endocrinology and metabolism2022

Utility of Continuous Glucose Monitoring vs Meal Study in Detecting Hypoglycemia After Gastric Bypass.

Henri Honka, Janet Chuang, David D'Alessio, Marzieh Salehi

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Henri HonkaDivision of Diabetes, University of Texas Health Science Center, San Antonio, TX 78229, USA.ORCID 0000-0003-1389-6355
Janet ChuangCincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3026, USA.
David D'AlessioUniversity of Cincinnati College of Medicine, Department of Medicine, Cincinnati, OH 45267, USA.
Marzieh SalehiDivision of Diabetes, University of Texas Health Science Center, San Antonio, TX 78229, USA.ORCID 0000-0003-4764-739X
The University of Texas Health Science Center at San Antonio · USCincinnati Children's Hospital Medical Center · USUniversity of Cincinnati Medical Center · US

Funding

The Weight-Independent Effects of Bariatric Surgeries on Islet Cell FunctionR01DK105379 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SALEHI, MARZIEH · 2015 to 2020
$2.4M
Finnish Cultural Foundation 00180071NIDDK NIH HHS R01 DK105379
6 · The paper itself

Abstract

contextGastric bypass (GB) increases postprandial glucose excursion, which in turn can predispose to the late complication of hypoglycemia. Diagnosis remains challenging and requires documentation of symptoms associated with low glucose and relief of symptom when glucose is normalized (Whipple triad).

objectiveTo compare the yield of mixed meal test (MMT) and continuous glucose monitoring system (CGMS) in detecting hypoglycemia after GB.

settingThe study was conducted at General Clinical Research Unit, Cincinnati Children's Hospital (Cincinnati, OH, USA).

methodsGlucose profiles were evaluated in 15 patients with documented recurrent clinical hypoglycemia after GB, 8 matched asymptomatic GB subjects, and 9 healthy weight-matched nonoperated controls using MMT in a control setting and CGMS under free-living conditions.

resultsPatients with prior GB had larger glucose variability during both MMT and CGMS when compared with nonsurgical controls regardless of their hypoglycemic status. Sensitivity (71 vs 47%) and specificity (100 vs 88%) of MMT in detecting hypoglycemia was superior to CGMS.

conclusionsOur findings indicate that a fixed carbohydrate ingestion during MMT is a more reliable test to diagnose GB-related hypoglycemia compared with CGMS during free-living state.

Indexed as

Gastric BypassHypoglycemiaObesity, MorbidBlood GlucoseBlood Glucose Self-MonitoringChildHumansInsulinBlood GlucoseInsulinmixed meal testpost-bariatric hypoglycemia syndromeRoux-en-Y gastric bypass

Identifiers

PMID34935944
PMCPMC9016438
OpenAlexW4200025328

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.