ArticleJournal of functional biomaterials2021
Design of Asymmetric Nanofibers-Membranes Based on Polyvinyl Alcohol and Wool-Keratin for Wound Healing Applications.
Article in Journal of functional biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Greener synthesis of silver nanoparticles fromFrontiers in cellular and infection microbiology · 2026Article
- Modular design of biomimetic electrospun keratin composites for tunable gaseous sorption inspired by reptile eggshells.Materials today. Bio · 2025Article
- A review of the current state of natural biomaterials in wound healing applications.Frontiers in bioengineering and biotechnology · 2024Review
- Microemulsion-Based Keratin-Chitosan Gel for Improvement of Skin Permeation/Retention and Activity of Curcumin.Gels (Basel, Switzerland) · 2023Article
- Hydrogel-Inducing Graphene-Oxide-Derived Core-Shell Fiber Composite for Antibacterial Wound Dressing.International journal of molecular sciences · 2023Article
- Wool Keratin Nanofibers for Bioinspired and Sustainable Use in Biomedical Field.Journal of functional biomaterials · 2022Review
- Preparation Methods and Functional Characteristics of Regenerated Keratin-Based Biofilms.Polymers · 2022Review
- Electro Fluid Dynamics: A Route to Design Polymers and Composites for Biomedical and Bio-Sustainable Applications.Polymers · 2022Review
- Review
- Electrospun Sulfonatocalix[4]arene Loaded Blended Nanofibers: Process Optimization and In Vitro Studies.Pharmaceutics · 2022Article
- Wool Keratin-Based Nanofibres-In Vitro Validation.Bioengineering (Basel, Switzerland) · 2021Article
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Authors and funding
6 authors.
Funding
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Abstract
The development of asymmetric membranes-i.e., matching two fibrous layers with selected composition and morphological properties to mimic both the epidermis and dermis-currently represents one of the most promising strategies to support skin regeneration during the wound healing process. Herein, a new asymmetric platform fabricated by a sequential electrospinning process was investigated. The top layer comprises cross-linked polyvinylalcohol (PVA) nanofibers (NFs)-from water solution-to replicate the epidermis's chemical stability and wettability features. Otherwise, the bottom layer is fabricated by integrating PVA with wool-keratin extracted via sulfitolysis. This protein is a biocompatibility polymer with excellent properties for dermis-like structures. Morphological characterization via SEM supported by image analysis showed that the asymmetric membrane exhibited average fiber size-max frequency diameter 450 nm, range 1.40 μm-and porosity suitable for the healing process. FTIR-spectrums confirmed the presence of keratin in the bottom layer and variations of keratin-secondary structures. Compared with pure PVA-NFs, keratin/PVA-NFs showed a significant improvement in cell adhesion in in vitro tests. In perspective, these asymmetric membranes could be promisingly used to confine active species (i.e., antioxidants, antimicrobials) to the bottom layer to support specific cell activities (i.e., proliferation, differentiation) in wound healing applications.
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