Evidence map›Paper›PMID 34944089›Full record

ArticleCells2021

Neutrophil-Derived Extracellular Vesicles Activate Platelets after Pneumolysin Exposure.

Eleftheria Letsiou, Luiz Gustavo Teixeira Alves, Matthias Felten, Timothy J Mitchell, Holger C Müller-Redetzky, Steven M Dudek, Martin Witzenrath

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. The roles of glycerophospholipids in the aging retina and age-related macular degeneration.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Review
  5. The dual promise of extracellular vesicles in lung diseases: towards reliable biomarkers and drug delivery vectors.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  6. Review
  7. Review
  8. Review
  9. Microbiology spectrum · 2024
    Article
  10. Platelets in Alcohol-Associated Liver Disease: Interaction With Neutrophils.Cellular and molecular gastroenterology and hepatology · 2024
    Review
  11. Biofilm-dispersed pneumococci induce elevated leukocyte and platelet activation.Frontiers in cellular and infection microbiology · 2024
    Article
  12. Extracellular Vesicles and Their Role in Lung Infections.International journal of molecular sciences · 2023
    Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Eleftheria LetsiouDivision of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, IL 60612, USA.
Luiz Gustavo Teixeira AlvesDivision of Pulmonary Inflammation, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Univeristät Berlin and Humboldt-Univeristät zu Berlin, 10117 Berlin, Germany.
Matthias FeltenDivision of Pulmonary Inflammation, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Univeristät Berlin and Humboldt-Univeristät zu Berlin, 10117 Berlin, Germany.ORCID 0000-0001-5808-5025
Timothy J MitchellInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Holger C Müller-RedetzkyDivision of Pulmonary Inflammation, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Univeristät Berlin and Humboldt-Univeristät zu Berlin, 10117 Berlin, Germany.
Steven M DudekDivision of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0001-5624-0714
Martin WitzenrathDivision of Pulmonary Inflammation, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Univeristät Berlin and Humboldt-Univeristät zu Berlin, 10117 Berlin, Germany.ORCID 0000-0002-9787-5633
Humboldt-Universität zu Berlin · DEJustus-Liebig-Universität Gießen · DEUniversity of Birmingham · GBUniversity of Illinois Chicago · US

Funding

Deutsche Forschungsgemeinschaft SFB-TR84 C6,9German Ministry of Education and Research CAPSyS (01ZX1304B), SYMPATH (FKZ 01ZX1906A) and PROVID project (FKZ 01KI20160A)Marie Curie 9019-2015
6 · The paper itself

Abstract

Pneumolysin (PLY) is a pore-forming toxin of

Indexed as

AnimalsBacterial ProteinsBlood PlateletsExtracellular TrapsExtracellular VesiclesHumansMiceNeutrophil ActivationNeutrophilsPlatelet ActivationStreptolysinsBacterial ProteinsplY protein, Streptococcus pneumoniaeStreptolysinslung injurymicrovesiclesNETspneumoniaStreptococcus pneumoniae

Identifiers

PMID34944089
PMCPMC8700313
OpenAlexW4200381723

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.