Evidence map›Paper›PMID 34944648›Full record

ArticleBiomedicines2021

Plasminogen Deficiency Significantly Reduces Vascular Wall Disease in a Murine Model of Type IIa Hypercholesterolemia.

Takayuki Iwaki, Tomohiro Arakawa, Mayra J Sandoval-Cooper, Denise L Smith, Deborah Donahue, Victoria A Ploplis, Kazuo Umemura, Francis J Castellino

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Connecting impaired fibrinolysis and dyslipidemia.Research and practice in thrombosis and haemostasis · 2024
    Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Takayuki IwakiThe W. M. Keck Center for Transgene Research, The Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.ORCID 0000-0003-3735-3718
Tomohiro ArakawaDepartment of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Mayra J Sandoval-CooperThe W. M. Keck Center for Transgene Research, The Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Denise L SmithThe W. M. Keck Center for Transgene Research, The Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Deborah DonahueThe W. M. Keck Center for Transgene Research, The Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Victoria A PloplisThe W. M. Keck Center for Transgene Research, The Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Kazuo UmemuraDepartment of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Francis J CastellinoThe W. M. Keck Center for Transgene Research, The Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
University of Notre Dame · USHamamatsu University School of Medicine · JP

Funding

Health Labor Sciences Research Grant for Research on Measures for Intractable Diseases H27NN018B2HUSM Grant-in-Aid NAJapan Agency for Medical Research and Development 15lm0103009j0004Japan Society for the Promotion of Science 17K10666Japan Society for the Promotion of Science 20890093Japan Society for the Promotion of Science 22790247National Institute of Health HL-073750Uehara Memorial Foundation NA
6 · The paper itself

Abstract

The fibrinolytic system has been implicated in the genesis and progression of atherosclerosis. It has been reported that a plasminogen (Pg) deficiency (

Indexed as

apobec-1atherosclerosisfoam cellsLDL receptorplasminogen

Identifiers

PMID34944648
PMCPMC8698429
OpenAlexW4200002797

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.