Evidence map›Paper›PMID 34944744›Full record

ArticleBiomedicines2021

A Hyaluronic Acid Demilune Scaffold and Polypyrrole-Coated Fibers Carrying Embedded Human Neural Precursor Cells and Curcumin for Surface Capping of Spinal Cord Injuries.

Hoda Elkhenany, Pablo Bonilla, Esther Giraldo, Ana Alastrue Agudo, Michael J Edel, María Jesus Vicent, Fernando Gisbert Roca, Cristina Martínez Ramos, Laura Rodríguez Doblado, Manuel Monleón Pradas and 1 more

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Poly(curcumin-Journal of neural engineering · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Recent Advances in the Treatment of Spinal Cord Injury.The archives of bone and joint surgery · 2024
    Review
  12. In Vitro Models of Amyotrophic Lateral Sclerosis.Cellular and molecular neurobiology · 2023
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Novel Strategies for Spinal Cord Regeneration.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Hoda ElkhenanyNeuronal and Tissue Regeneration Laboratory, Centro de Investigación Príncipe Felipe, 46012 Valencia, Spain.ORCID 0000-0003-2638-8640
Pablo BonillaNeuronal and Tissue Regeneration Laboratory, Centro de Investigación Príncipe Felipe, 46012 Valencia, Spain.
Esther GiraldoNeuronal and Tissue Regeneration Laboratory, Centro de Investigación Príncipe Felipe, 46012 Valencia, Spain.ORCID 0000-0001-5488-3011
Ana Alastrue AgudoNeuronal and Tissue Regeneration Laboratory, Centro de Investigación Príncipe Felipe, 46012 Valencia, Spain.ORCID 0000-0002-9326-2119
Michael J EdelUnit of Anatomy and Embryology, School of Medicine, Autonomous University of Barcelona, 08193 Barcelona, Spain.ORCID 0000-0002-5619-8680
María Jesus VicentPolymer Therapeutics Laboratory, Centro de Investigación Príncipe Felipe, 46012 Valencia, Spain.ORCID 0000-0001-7771-3373
Fernando Gisbert RocaCenter for Biomaterials and Tissue Engineering, Universitat Politècnica de València, 46022 Valencia, Spain.
Cristina Martínez RamosCenter for Biomaterials and Tissue Engineering, Universitat Politècnica de València, 46022 Valencia, Spain.
Laura Rodríguez DobladoCenter for Biomaterials and Tissue Engineering, Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0002-0121-9181
Manuel Monleón PradasCenter for Biomaterials and Tissue Engineering, Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0001-6457-0414
Victoria Moreno ManzanoNeuronal and Tissue Regeneration Laboratory, Centro de Investigación Príncipe Felipe, 46012 Valencia, Spain.ORCID 0000-0002-6035-9491
Centro de Investigacion Principe Felipe · ESUniversitat Politècnica de València · ESUniversitat Autònoma de Barcelona · ES

Funding

Agencia Estatal de investigación RTI2018-095872-B-C21 and -C22/ERDFEuropean Commission H2020-FETOPEN-2018-2019-2020-01Women for Africa Foundation n/s
6 · The paper itself

Abstract

Tissue engineering, including cell transplantation and the application of biomaterials and bioactive molecules, represents a promising approach for regeneration following spinal cord injury (SCI). We designed a combinatorial tissue-engineered approach for the minimally invasive treatment of SCI-a hyaluronic acid (HA)-based scaffold containing polypyrrole-coated fibers (PPY) combined with the RAD16-I self-assembling peptide hydrogel (Corning

Indexed as

biomaterialscurcuminhyaluronic acidinduced neural progenitor cellsPuraMatrix hydrogelspinal cord injury

Identifiers

PMID34944744
PMCPMC8698735
OpenAlexW4200050956

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.