Evidence map›Paper›PMID 34945127›Full record

ReviewJournal of clinical medicine2021

Extramedullary Hematopoiesis of the Liver and Spleen.

Diana Cenariu, Sabina Iluta, Alina-Andreea Zimta, Bobe Petrushev, Liren Qian, Noemi Dirzu, Ciprian Tomuleasa, Horia Bumbea, Florin Zaharie

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. CD71BMC nephrology · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Liver histopathology in dogs with naturally acquiredFrontiers in veterinary science · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. A Neutrophil Storage Pool in the Fetal Liver is the Principal Source of the Postnatal Neutrophil Surge.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  17. Article
  18. Review
  19. Differential expression of a disease-associatedbioRxiv : the preprint server for biology · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Diana CenariuMedfuture Research Center for Advanced Medicine, School of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.
Sabina IlutaDepartment of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, 400124 Cluj-Napoca, Romania.
Alina-Andreea ZimtaMedfuture Research Center for Advanced Medicine, School of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.ORCID 0000-0003-3856-3784
Bobe PetrushevMedfuture Research Center for Advanced Medicine, School of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.
Liren QianDepartment of Hematology, 5th Medical Center of the People's Liberation Army General Hospital, Beijing 100037, China.ORCID 0000-0002-7750-9177
Noemi DirzuMedfuture Research Center for Advanced Medicine, School of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.ORCID 0000-0002-4137-0281
Ciprian TomuleasaMedfuture Research Center for Advanced Medicine, School of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.ORCID 0000-0001-5500-1519
Horia BumbeaDepartment of Hematology, Carol Davila University of Medicine and Pharmacy, 400004 Bucharest, Romania.ORCID 0000-0002-3706-3166
Florin ZaharieDepartment of Surgery, Iuliu Hatieganu University of Medicine and Pharmacy, 400124 Cluj-Napoca, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hematopoiesis is the formation of blood cellular components and, consequently, immune cells. In a more complete definition, this process refers to the formation, growth, maturation, and specialization of blood cells, from the hematopoietic stem cell, through the hematopoietic progenitor cells, to the s pecialized blood cells. This process is tightly regulated by several elements of the bone marrow microenvironment, such as growth factors, transcription factors, and cytokines. During embryonic and fetal development, hematopoiesis takes place in different organs: the yolk sac, the aorta-gonad mesonephros region, the lymph nodes, and not lastly, the fetal liver and the spleen. In the current review, we describe extramedullary hematopoiesis of the spleen and liver, with an emphasis on myeloproliferative conditions.

Indexed as

chronic myeloproliferative neoplasmsembryologyextramedullary hematopoiesisspleen and liver

Identifiers

PMID34945127
PMCPMC8707658

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.