Evidence map›Paper›PMID 34947859›Full record

ArticleLife (Basel, Switzerland)2021

Clinical Relevance of Secreted Small Noncoding RNAs in an Embryo Implantation Potential Prediction at Morula and Blastocyst Development Stages.

Angelika V Timofeeva, Ivan S Fedorov, Maria A Shamina, Vitaliy V Chagovets, Nataliya P Makarova, Elena A Kalinina, Tatiana A Nazarenko, Gennady T Sukhikh

Open access · goldAbstract read
In one paragraph

Article in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Differential Expression of Small Non-Coding RNAs in Uterine Leiomyomas.International journal of molecular sciences · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Cellular and Molecular Nature of Fragmentation of Human Embryos.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Angelika V TimofeevaLaboratory of Applied Transcriptomics, Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997 Moscow, Russia.ORCID 0000-0003-2324-9653
Ivan S FedorovLaboratory of Applied Transcriptomics, Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997 Moscow, Russia.
Maria A ShaminaDepartment of Assisted Reproductive Technologies, Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997 Moscow, Russia.
Vitaliy V ChagovetsLaboratory of Proteomics and Metabolomics of Human Reproduction, Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997 Moscow, Russia.
Nataliya P MakarovaDepartment of Assisted Reproductive Technologies, Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997 Moscow, Russia.
Elena A KalininaDepartment of Assisted Reproductive Technologies, Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997 Moscow, Russia.
Tatiana A NazarenkoKulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997 Moscow, Russia.
Gennady T SukhikhKulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997 Moscow, Russia.
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation · RUMinistry of Health of the Russian Federation · RU

Funding

state project "Solving the problem of infertility in modern conditions by developing a clinical and diagnostic model of infertile marriage and the use of innovative technologies in assisted reproduc-tion programs" 19.15-2021
6 · The paper itself

Abstract

Despite the improvements in biotechnological approaches and the selection of controlled ovarian hyperstimulation protocols, the resulting pregnancy rate from in vitro fertilization (IVF) protocols still does not exceed 30-40%. In this connection, there is an acute question of the development of a non-invasive, sensitive, and specific method for assessing the implantation potential of an embryo. A total of 110 subfertile couples were included in the study to undergo the IVF/ICSI program. Obtained embryos for transfer into the uterine cavity of patient cohort 1 (

Indexed as

blastocystdeep sequencinglogistic regression modelmiRNAmorulapiRNAqRT-PCRsncRNA gene-target

Identifiers

PMID34947859
PMCPMC8706231
OpenAlexW3217227232

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.