Evidence map›Paper›PMID 34948139›Full record

ArticleInternational journal of molecular sciences2021

1,25-Dihydroxyvitamin D3 and 20-Hydroxyvitamin D3 Upregulate LAIR-1 and Attenuate Collagen Induced Arthritis.

Linda K Myers, Michael Winstead, John D Kee, Jeoungeun J Park, Sicheng Zhang, Wei Li, Ae-Kyung Yi, John M Stuart, Edward F Rosloniec, David D Brand and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
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  9. Vitamin D Signaling in Psoriasis: Pathogenesis and Therapy.International journal of molecular sciences · 2022
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Linda K MyersDepartment of Pediatrics, University of Tennessee Health Science Center, 50 N. Dunlap, Rm. 461R, Memphis, TN 38103, USA.ORCID 0000-0001-5268-1870
Michael WinsteadDepartment of Medicine, University of Tennessee Health Science Center, 956 Court Ave., Memphis, TN 38163, USA.
John D KeeDepartment of Medicine, University of Tennessee Health Science Center, 956 Court Ave., Memphis, TN 38163, USA.
Jeoungeun J ParkDepartment of Medicine, University of Tennessee Health Science Center, 956 Court Ave., Memphis, TN 38163, USA.
Sicheng ZhangDepartment of Pharmaceutical Sciences, University of Tennessee Health Science Center, 881 Madison Ave, Memphis, TN 38103, USA.ORCID 0000-0003-3798-7550
Wei LiDepartment of Pharmaceutical Sciences, University of Tennessee Health Science Center, 881 Madison Ave, Memphis, TN 38103, USA.ORCID 0000-0002-9522-4474
Ae-Kyung YiDepartment of Microbiology-Immunology-Biochemistry, University of Tennessee Health Science Center, 858 Madison Ave., Memphis, TN 38163, USA.
John M StuartDepartment of Medicine, University of Tennessee Health Science Center, 956 Court Ave., Memphis, TN 38163, USA.
Edward F RosloniecMemphis Veterans Affairs Medical Center, 1030 Jefferson Ave., Memphis, TN 38104, USA.
David D BrandMemphis Veterans Affairs Medical Center, 1030 Jefferson Ave., Memphis, TN 38104, USA.ORCID 0000-0002-9260-7963
Robert C TuckeySchool of Molecular Sciences, University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia.ORCID 0000-0002-5022-4729
Andrzej T SlominskiDepartment of Dermatology, University of Alabama at Birmingham 500 22nd St. S, Birmingham, AL 35294, USA.ORCID 0000-0001-8963-3995
Arnold E PostlethwaiteDepartment of Medicine, University of Tennessee Health Science Center, 956 Court Ave., Memphis, TN 38163, USA.
Andrew H KangDepartment of Medicine, University of Tennessee Health Science Center, 956 Court Ave., Memphis, TN 38163, USA.
University of Tennessee Health Science Center · USMemphis VA Medical Center · USThe University of Western Australia · AUUniversity of Alabama at Birmingham · US

Funding

Mechanism of action and function of novel secosteroid 20(OH)D3 in the skinR01AR073004 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ANDRZEJ T SLOMINSKI · 2018 to 2026
$2.9M
Inhibitory Receptors and Autoimmune ArthritisR01AR069010 · NIAMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI YI, AE-KYUNG · 2016 to 2021
$1.7M
Significance of metabolic activation of lumisterol in the skinR01AR071189 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SLOMINSKI, ANDRZEJ T · 2017 to 2021
$1.6M
Canonical and non-canonical vitamin D activation pathways in systemic lupusR21AI149267 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RAMAN, CHANDER, SLOMINSKI, ANDRZEJ T · 2020 to 2021
$408k
BLRD VA I01 BX004293National Institue of Health R01AR073004, R01AR071189, R21 AI149267, AR069010, AR064825, R21AR063242NIAID NIH HHS R21 AI149267NIAMS NIH HHS R01 AR069010NIAMS NIH HHS R01 AR071189NIAMS NIH HHS R01 AR073004Veterans Affairs 1I01BX004293-01A1
6 · The paper itself

Abstract

Vitamin D plays a crucial role in regulation of the immune response. However, treatment of autoimmune diseases with 1,25-dihydroxyvitamin D3 [1,25(OH)

Indexed as

AnimalsArthritis, ExperimentalCalcifediolCalcitriolMiceMice, KnockoutReceptors, ImmunologicT-LymphocytesUp-Regulation20-hydroxyvitamin D3CalcifediolCalcitriolleukocyte-associated immunoglobulin-like receptor 1Receptors, Immunologic20S(OH)D3arthritisautoimmunityLAIR-1vitamin D

Identifiers

PMID34948139
PMCPMC8709360
OpenAlexW4200207012

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.