Evidence map›Paper›PMID 34948262›Full record

ArticleInternational journal of molecular sciences2021

Prothoracicostatic Activity of the Ecdysis-Regulating Neuropeptide Crustacean Cardioactive Peptide (CCAP) in the Desert Locust.

Lina Verbakel, Cynthia Lenaerts, Rania Abou El Asrar, Caroline Zandecki, Evert Bruyninckx, Emilie Monjon, Elisabeth Marchal, Jozef Vanden Broeck

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lina VerbakelMolecular Developmental Physiology and Signal Transduction, KU Leuven, Naamsestraat 59, P.O. Box 2465, B-3000 Leuven, Belgium.ORCID 0000-0003-0490-8406
Cynthia LenaertsMolecular Developmental Physiology and Signal Transduction, KU Leuven, Naamsestraat 59, P.O. Box 2465, B-3000 Leuven, Belgium.
Rania Abou El AsrarMolecular Developmental Physiology and Signal Transduction, KU Leuven, Naamsestraat 59, P.O. Box 2465, B-3000 Leuven, Belgium.
Caroline ZandeckiMolecular Developmental Physiology and Signal Transduction, KU Leuven, Naamsestraat 59, P.O. Box 2465, B-3000 Leuven, Belgium.ORCID 0000-0002-7898-0550
Evert BruyninckxMolecular Developmental Physiology and Signal Transduction, KU Leuven, Naamsestraat 59, P.O. Box 2465, B-3000 Leuven, Belgium.
Emilie MonjonMolecular Developmental Physiology and Signal Transduction, KU Leuven, Naamsestraat 59, P.O. Box 2465, B-3000 Leuven, Belgium.
Elisabeth MarchalMolecular Developmental Physiology and Signal Transduction, KU Leuven, Naamsestraat 59, P.O. Box 2465, B-3000 Leuven, Belgium.
Jozef Vanden BroeckMolecular Developmental Physiology and Signal Transduction, KU Leuven, Naamsestraat 59, P.O. Box 2465, B-3000 Leuven, Belgium.ORCID 0000-0001-7653-0516
KU Leuven · BEIMEC · BE

Funding

European Union's Horizon 2020 Research and Innovation program 634361Research Foundation - Flanders G090919NResearch Foundation - Flanders VS.034.16N
6 · The paper itself

Abstract

Accurate control of innate behaviors associated with developmental transitions requires functional integration of hormonal and neural signals. Insect molting is regulated by a set of neuropeptides, which trigger periodic pulses in ecdysteroid hormone titers and coordinate shedding of the old cuticle during ecdysis. In the current study, we demonstrate that crustacean cardioactive peptide (CCAP), a structurally conserved neuropeptide described to induce the ecdysis motor program, also exhibits a previously unknown prothoracicostatic activity to regulate ecdysteroid production in the desert locust,

Indexed as

AnimalsEcdysteroidsGene ExpressionGene Expression Regulation, DevelopmentalGrasshoppersInsect HormonesMoltingNeuropeptidesPeptidesReceptors, G-Protein-CoupledSignal Transductioncrustacean cardioactive peptideEcdysteroidsInsect HormonesNeuropeptidesPeptidesReceptors, G-Protein-Coupledecdysis behaviorinsectneuroendocrinologyneuropeptidesprothoracic glandreceptorsteroid hormone

Identifiers

PMID34948262
PMCPMC8704491
OpenAlexW4200322468

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.