Evidence map›Paper›PMID 34948266›Full record

ArticleInternational journal of molecular sciences2021

Relationship of In Vitro Toxicity of Technetium-99m to Subcellular Localisation and Absorbed Dose.

Ines M Costa, Noor Siksek, Alessia Volpe, Francis Man, Katarzyna M Osytek, Elise Verger, Giuseppe Schettino, Gilbert O Fruhwirth, Samantha Y A Terry

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Radionuclides for Targeted Therapy: Physical Properties.Molecules (Basel, Switzerland) · 2022
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ines M CostaDepartment of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.
Noor SiksekDepartment of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.
Alessia VolpeMemorial Sloan Kettering Cancer Center, Molecular Imaging Group, Department of Radiology, New York, NY 10065, USA.ORCID 0000-0003-3087-9178
Francis ManDepartment of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.ORCID 0000-0002-5076-2180
Katarzyna M OsytekDepartment of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.
Elise VergerDepartment of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.
Giuseppe SchettinoNational Physical Laboratory, Department of Medical Radiation Sciences, Teddington TW11 0LW, UK.
Gilbert O FruhwirthComprehensive Cancer Centre, Imaging Therapies and Cancer Group, School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK.
Samantha Y A TerryDepartment of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.ORCID 0000-0002-6497-6681

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Academy of Medical Sciences SBF001\1019Cancer Research UK 21153Cancer Research UK C48390/A21153Medical Research Council MR/N013700/1NCI NIH HHS P30 CA008748Wellcome Trust 203148/Z/16/ZWellcome Trust WT 203148/Z/16/Z
6 · The paper itself

Abstract

Auger electron-emitters increasingly attract attention as potential radionuclides for molecular radionuclide therapy in oncology. The radionuclide technetium-99m is widely used for imaging; however, its potential as a therapeutic radionuclide has not yet been fully assessed. We used MDA-MB-231 breast cancer cells engineered to express the human sodium iodide symporter-green fluorescent protein fusion reporter (hNIS-GFP; MDA-MB-231.hNIS-GFP) as a model for controlled cellular radionuclide uptake. Uptake, efflux, and subcellular location of the NIS radiotracer [

Indexed as

Breast NeoplasmsCell Line, TumorDose-Response Relationship, RadiationHumansIodine RadioisotopesRadiopharmaceuticalsSodium-Iodide SymportersSymportersTechnetiumTissue DistributionIodine RadioisotopesRadiopharmaceuticalsSodium-Iodide SymportersSymportersTechnetiumTechnetium-99auger electron therapydosimetrymolecular radionuclide therapyradiobiologysodium iodide symportertechnetiumtriple-negative breast cancer cells

Identifiers

PMID34948266
PMCPMC8703725

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.