Evidence map›Paper›PMID 34948324›Full record

ArticleInternational journal of molecular sciences2021

The Use of ProteoTuner Technology to Study Nuclear Factor κB Activation by Heavy Ions.

Arif Ali Chishti, Christa Baumstark-Khan, Hasan Nisar, Yueyuan Hu, Bikash Konda, Bernd Henschenmacher, Luis F Spitta, Claudia Schmitz, Sebastian Feles, Christine E Hellweg

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Arif Ali ChishtiRadiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, D-51147 Köln, Germany.
Christa Baumstark-KhanRadiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, D-51147 Köln, Germany.
Hasan NisarRadiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, D-51147 Köln, Germany.
Yueyuan HuRadiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, D-51147 Köln, Germany.
Bikash KondaRadiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, D-51147 Köln, Germany.
Bernd HenschenmacherRadiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, D-51147 Köln, Germany.
Luis F SpittaRadiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, D-51147 Köln, Germany.
Claudia SchmitzRadiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, D-51147 Köln, Germany.
Sebastian FelesRadiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, D-51147 Köln, Germany.
Christine E HellwegRadiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, D-51147 Köln, Germany.ORCID 0000-0002-2223-3580
Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR) · DEPakistan Institute of Engineering and Applied Sciences · PKShenzhen University · CNUniversity Hospital Bonn · DE

Funding

China Scholarship Council Y.H.European Union ENSAR2-TNA contract HORIZON2020 Program grant agreement n°654002European Union ENSAR contract in the framework of FP7 Integrated Infrastructure Initiative, grant agreement no. 262010European Union EURONSGerman Academic Exchange Service HEC - HRDI-UESTP's / UET's - Faculty TrainingHelmholtz Association of German Research Centres VH-KO-300
6 · The paper itself

Abstract

Nuclear factor κB (NF-κB) activation might be central to heavy ion-induced detrimental processes such as cancer promotion and progression and sustained inflammatory responses. A sensitive detection system is crucial to better understand its involvement in these processes. Therefore, a DD-tdTomato fluorescent protein-based reporter system was previously constructed with human embryonic kidney (HEK) cells expressing DD-tdTomato as a reporter under the control of a promoter containing NF-κB binding sites (HEK-pNFκB-DD-tdTomato-C8). Using this reporter cell line, NF-κB activation after exposure to different energetic heavy ions (

Indexed as

Cell LineCell NucleusHeavy IonsHEK293 CellsHumansLuminescent ProteinsNF-kappa BPromoter Regions, GeneticTechnologyLuminescent ProteinsNF-kappa BDD-tdTomatofluorescent proteingalactic cosmic raysheavy ionsnuclear factor κBProteoTuner systemreporter systemspace missionstdTomatoX-rays

Identifiers

PMID34948324
PMCPMC8703744
OpenAlexW4200048306

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.