Evidence map›Paper›PMID 34948337›Full record

ArticleInternational journal of molecular sciences2021

Pharmacologically Targeting the Fibroblast Growth Factor 14 Interaction Site on the Voltage-Gated Na

Nolan M Dvorak, Cynthia M Tapia, Aditya K Singh, Timothy J Baumgartner, Pingyuan Wang, Haiying Chen, Paul A Wadsworth, Jia Zhou, Fernanda Laezza

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. mTORC2-NaChannels (Austin, Tex.) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Inhibition of the GSK3β/Nav1.6 complex suppresses early-stage Alzheimer's hyperexcitability.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Inhibition of the Akt/PKB Kinase Increases NaInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nolan M DvorakDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 75901, USA.ORCID 0000-0003-1280-9918
Cynthia M TapiaDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 75901, USA.
Aditya K SinghDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 75901, USA.
Timothy J BaumgartnerDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 75901, USA.
Pingyuan WangDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 75901, USA.
Haiying ChenDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 75901, USA.
Paul A WadsworthDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 75901, USA.ORCID 0000-0002-4562-7830
Jia ZhouDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 75901, USA.ORCID 0000-0002-2811-1090
Fernanda LaezzaDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 75901, USA.ORCID 0000-0003-1141-1852

Funding

HOUSTON AREA MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008280 · NIGMS · RICE UNIVERSITY · PI WENSEL, THEODORE G · 1988 to 2023
$8.0M
Molecular Mechanisms of Environmental InjuryT32ES007254 · NIEHS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI AMEREDES, BILL T · 1990 to 2022
$6.6M
Neurotrophin-dependent regulation of voltage-gated sodium channelsR01MH124351 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAEZZA, FERNANDA · 2020 to 2024
$3.0M
Neurotoxicology of deltamethrin in the developing brainR01ES031823 · NIEHS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GREEN, THOMAS ARTHUR, LAEZZA, FERNANDA · 2020 to 2024
$2.8M
Validation of FGF14 as a New Molecular Target of GSK3R01MH095995 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAEZZA, FERNANDA · 2012 to 2016
$1.9M
Discovery of Chemical Probes for Psychiatric Disorders and AddictionR01MH111107 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAEZZA, FERNANDA, ZHOU, JIA · 2016 to 2018
$1.6M
Core Center for Translational Addiction SciencesP30DA028821 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CUNNINGHAM, KATHRYN A. · 2009 to 2010
$1.5M
John D. Stobo, M.D., Distinguished Chair Endowment FundJohn Sealy Memorial Endowment FundNIEHS NIH HHS R01 ES031823NIGMS NIH HHS T32 GM008280NIH HHS P30 DA028821NIH HHS R01 MH095995NIH HHS R01 MH111107NIH HHS T32 AG067952-01NIH HHS T32 ES007254NIH HHS T32 GM008280NIMH NIH HHS R01 MH124351UTMB Technology Commercialization Program
6 · The paper itself

Abstract

Voltage-gated Na

Indexed as

Protein DomainsAnimalsFibroblast Growth FactorsHEK293 CellsHumansMiceMolecular Docking SimulationNAV1.6 Voltage-Gated Sodium ChannelNeuronsNucleus AccumbensPeptidomimeticsProtein Bindingfibroblast growth factor 14Fibroblast Growth FactorsNAV1.6 Voltage-Gated Sodium ChannelPeptidomimeticsfibroblast growth factor 14 (FGF14)medium spiny neurons (MSNs)neurotherapeuticsnucleus accumbens (NAc)peptidomimeticsprotein–protein interactions (PPIs)voltage-gated Na+ (Nav) channels

Identifiers

PMID34948337
PMCPMC8708424

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.