Evidence mapPaperPMID 34948545Full record

ReviewInternational journal of environmental research and public health2021

Drug-Drug Interactions in Vestibular Diseases, Clinical Problems, and Medico-Legal Implications.

Giulio Di Mizio, Gianmarco Marcianò, Caterina Palleria, Lucia Muraca, Vincenzo Rania, Roberta Roberti, Giuseppe Spaziano, Amalia Piscopo, Valeria Ciconte, Nunzio Di Nunno and 8 more

Open access · goldAbstract readReview
In one paragraph

Review in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Vestibular compensation: extended review.Frontiers in neurology · 2026
    Review
  3. Review
  4. Meclizine Use and Subsequent Falls Among Patients With Dizziness.JAMA otolaryngology-- head & neck surgery · 2025
    Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 1 country.

Giulio Di MizioDepartment of Law, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy.ORCID 0000-0001-7279-3693
Gianmarco MarcianòDepartment of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, 88100 Catanzaro, Italy.
Caterina PalleriaDepartment of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, 88100 Catanzaro, Italy.
Lucia MuracaDepartment of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, 88100 Catanzaro, Italy.
Vincenzo RaniaDepartment of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, 88100 Catanzaro, Italy.
Roberta RobertiDepartment of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, 88100 Catanzaro, Italy.
Giuseppe SpazianoDepartment of Experimental Medicine L. Donatelli, Section of Pharmacology, School of Medicine, University of Campania Luigi Vanvitelli, 80123 Naples, Italy.
Amalia PiscopoDepartment of Law, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy.
Valeria CiconteDepartment of Law, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy.
Nunzio Di NunnoDepartment of History, Society and Studies on Humanity, University of Salento, 83100 Lecce, Italy.
Massimiliano EspositoDepartment of Medical, Surgical Sciences and Advanced Technologies "G. F. Ingrassia", University of Catania, 95121 Catania, Italy.
Pasquale ViolaUnit of Audiology, Department of Experimental and Clinical Medicine, Regional Centre of Cochlear Implants and ENT Diseases, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0000-0002-2352-1146
Davide PisaniUnit of Audiology, Department of Experimental and Clinical Medicine, Regional Centre of Cochlear Implants and ENT Diseases, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0000-0001-7486-0140
Giovambattista De SarroDepartment of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, 88100 Catanzaro, Italy.
Milena RaffiDepartment of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-7467-5591
Alessandro PirasDepartment of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0001-5974-0116
Giuseppe ChiarellaUnit of Audiology, Department of Experimental and Clinical Medicine, Regional Centre of Cochlear Implants and ENT Diseases, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0000-0002-9829-2229
Luca GallelliDepartment of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, 88100 Catanzaro, Italy.ORCID 0000-0003-0858-7902
Magna Graecia University · ITAzienda Ospedaliero Universitario Mater Domini · ITUniversity of Bologna · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Catania · ITUniversity of Salento · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral vestibular disease can be treated with several approaches (e.g., maneuvers, surgery, or medical approach). Comorbidity is common in elderly patients, so polytherapy is used, but it can generate the development of drug-drug interactions (DDIs) that play a role in both adverse drug reactions and reduced adherence. For this reason, they need a complex kind of approach, considering all their individual characteristics. Physicians must be able to prescribe and deprescribe drugs based on a solid knowledge of pharmacokinetics, pharmacodynamics, and clinical indications. Moreover, full information is required to reach a real therapeutic alliance, to improve the safety of care and reduce possible malpractice claims related to drug-drug interactions. In this review, using PubMed, Embase, and Cochrane library, we searched articles published until 30 August 2021, and described both pharmacokinetic and pharmacodynamic DDIs in patients with vestibular disorders, focusing the interest on their clinical implications and on risk management strategies.

Indexed as

Drug-Related Side Effects and Adverse ReactionsPharmaceutical PreparationsVestibular DiseasesAgedComorbidityDrug InteractionsHumansPharmaceutical Preparationsclinical practiceclinical risk managementdrug interactionselderlymedico legal aspectspolytherapysafety of carevertigovestibular disease

Identifiers

PMID34948545
PMCPMC8701970
OpenAlexW4200162677

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.