ReviewInternational journal of environmental research and public health2021
Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise.
Review in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Association Between Sedentary Behavior and the Development of New-Onset Chronic Pain in Older American Adults: Insights From the Health and Retirement Study.American journal of health promotion : AJHP · 2026Article
- Association of segmental body composition with cervical spine mobility in adults with nonspecific neck pain.Scientific reports · 2026Article
- Metaflammation's Role in Systemic Dysfunction in Obesity: A Comprehensive Review.International journal of molecular sciences · 2025Review
- Bayesian network imputation methods applied to multi-omics data identify putative causal relationships in a type 2 diabetes dataset containing incomplete data: An IMI DIRECT Study.PLoS genetics · 2025Article
- Association between novel inflammatory biomarkers SII, SIRI, and obesity in sedentary adults: NHANES 2007-2020.Scientific reports · 2025Article
- Associations Between Pain Intensity and Inflammatory Profile in Women with Android and Gynoid Obesity Diagnosed with Chronic Pain: An Observational Study.Journal of clinical medicine · 2025Article
- Demographic, cultural, and health correlates of physical activity and sports participation among adults in Kermanshah province, Iran.BMC public health · 2025Article
- Review
- Burden of cancer attributable to sedentary behaviour in Germany: an epidemiological analysis of survey data.BMJ open · 2025Article
- Identification of diagnostic genes for myocardial ischemia reperfusion injury associated with metabolic syndrome through the integration of bioinformatics analysis, molecular docking and experimental validation.Frontiers in immunology · 2025Article
- The Interplay Between Adipokines and Body Composition in Obesity and Metabolic Diseases.Cureus · 2025Review
- Review
- Associations between physical activity and prenatal depression and anxiety symptoms: a cross-sectional study.Frontiers in public health · 2025Article
- Time-Restricted Eating Benefits on Pulmonary Function and Postural Balance in Overweight or Obese Women.Nutrients · 2024Article
- Sedentary behaviour among elderly patients after total knee arthroplasty and its influencing factors.Scientific reports · 2024Article
- Exploring the Influence of a Physical Activity and Healthy Eating Program on Childhood Well-Being: A Comparative Study in Primary School Students.International journal of environmental research and public health · 2024Article
- Pain and the biochemistry of fibromyalgia: patterns of peripheral cytokines and chemokines contribute to the differentiation between fibromyalgia and controls and are associated with pain, fat infiltration and content.Frontiers in pain research (Lausanne, Switzerland) · 2024Article
- Chronic disease clusters are associated with prolonged, bothersome, and multisite musculoskeletal pain: a population-based study on Northern Finns.Annals of medicine · 2023Article
- Lifestyle changes are burdensome with my body broken by pain and obesity: patients' perspectives after pain rehabilitation.BMC musculoskeletal disorders · 2023Article
- Gender differences in the associations between body mass index, depression, anxiety, and stress among endocrinologists in China.BMC psychology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A sedentary lifestyle is associated with overweight/obesity, which involves excessive fat body accumulation, triggering structural and functional changes in tissues, organs, and body systems. Research shows that this fat accumulation is responsible for several comorbidities, including cardiovascular, gastrointestinal, and metabolic dysfunctions, as well as pathological pain behaviors. These health concerns are related to the crosstalk between adipose tissue and body systems, leading to pathophysiological changes to the latter. To deal with these health issues, it has been suggested that physical exercise may reverse part of these obesity-related pathologies by modulating the cross talk between the adipose tissue and body systems. In this context, this review was carried out to provide knowledge about (i) the structural and functional changes in tissues, organs, and body systems from accumulation of fat in obesity, emphasizing the crosstalk between fat and body tissues; (ii) the crosstalk between fat and body tissues triggering pain; and (iii) the effects of physical exercise on body tissues and organs in obese and non-obese subjects, and their impact on pathological pain. This information may help one to better understand this crosstalk and the factors involved, and it could be useful in designing more specific training interventions (according to the nature of the comorbidity).
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.