Evidence map›Paper›PMID 34951544›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2022

Region-specific distribution of transversal-axial tubule system organization underlies heterogeneity of calcium dynamics in the right atrium.

Di Lang, Roman Y Medvedev, Lucas Ratajczyk, Jingjing Zheng, Xiaoyu Yuan, Evi Lim, Owen Y Han, Hector H Valdivia, Alexey V Glukhov

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Caveolae-associated cAMP/CaJournal of molecular and cellular cardiology · 2023
    Article
  4. Regional Differences in CaInternational journal of molecular sciences · 2023
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Di LangDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.ORCID 0000-0003-3318-4208
Roman Y MedvedevDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.ORCID 0000-0003-1174-2993
Lucas RatajczykDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Jingjing ZhengDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Xiaoyu YuanDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Evi LimDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Owen Y HanDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Hector H ValdiviaDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Alexey V GlukhovDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.ORCID 0000-0003-2076-9688
University of Wisconsin–Madison · US

Funding

Ryanodine Receptors, Calcium-dependent Arrhythmias & HCMR01HL055438 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI VALDIVIA, HECTOR H · 1996 to 2023
$8.0M
Functional Microdomains in the Heart's Pacemaker: A New Dimension of Cardiac RemodelingR01HL141214 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Alexey V Glukhov · 2018 to 2026
$3.8M
NHLBI NIH HHS R01 HL055438NHLBI NIH HHS R01 HL141214
6 · The paper itself

Abstract

The atrial myocardium demonstrates the highly heterogeneous organization of the transversal-axial tubule system (TATS), although its anatomical distribution and region-specific impact on Ca

Indexed as

Calcium SignalingAction PotentialsAnimalsCalcium Channels, L-TypeCell MembraneHeart AtriaHumansMiceMice, Inbred C57BLMyocytes, CardiacRyanodine Receptor Calcium Release ChannelSodium-Calcium ExchangerCACNA1C protein, mouseCacna1d protein, mouseCalcium Channels, L-TypeNCX1 protein, mouseRyanodine Receptor Calcium Release ChannelSodium-Calcium Exchangeratriacalcium transientcardiomyocyteexcitation-contraction couplingtransversal-axial tubule

Identifiers

PMID34951544
PMCPMC8782648
OpenAlexW4200514602

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.